大鼠视觉发育可塑性关键期内视皮层神经元LTP和突触发育的-研究.pdf

a 2 differenceofLTPincidence increased weeks little(6／23)ingroup．The between was fP0．o first pre—and significantr)．LTP post-eye—opening occurredat 4 withnon·APV group days．2、Compared applied postnatal LTP of decreasedtheincidence (18／31)，APVapplication(3／24)significantly of after was rats were4 LTP open(P0．01)．There neurons，no eye pyramidal inducedwhenincubatedwithAPV．However．LTPcouldbeelicitedinalltlle 4cases washoutof 3 the anotherCasesrallfromⅣ一Ⅳ following drug．Ill horizontal couldn’tblockthe synapse)，APVapplication L]限induction．3、 Therewerethree ofEPSCsrecorded：silent types synapticresponse， monosynapticresponse，and ones．The ofsilent polysynaptic percentage in week i thanthatofthe response group(74．5％)wassignificantlyhigher other3 thedifference groups(9．5％)(P0．01)，while2、3、4weeks among was not incidence of EPSCsWas groups significant．Thepolysynaptic increased from7．69％of1 week to22．56％oftheother3