甘露醇衍生的新型手性配体的合成及其在不对称-华南师范大学学报.PDF

华南师范大学学报 (自然科学版 ) 2007年 2月 JOURNAL OF SOUTH CH INA NORMAL UN IVERSITY 2007年第 1期 Feb. 2007 ( NATURAL SCIENCE ED IT ION) No. 1, 2007 : 1000 5463( 2007) 01 0075 07 D 1 2* 1 1 1 1 欧 军, 陈亿新 , 刘军涛 , 冯爱青, 刘雪英 , 曾 志 ( 1. , 510631; 2. , 510405) : 1, 2, 5, 6 O D ( III) 1, 3, 4, 6 O D ( IV), 1, 3, 4, 6 O D ( V), 1, 3, 4, 6 O D ( VI). 4 ( 97. 4% 100% conv. ) ( 14% 31. 7% ee) . : ; ; : O62 : A APPLICATION OF CHIRAL DIOL LIGAND DERIVED FROM D MANNITOL IN ASYMMETRIC EPOXIDATION REACTION 1 2* 1 1 1 1 OU Jun , CHEN Y i xin , L IU Jun tao, FENG A i q ing , LIU Xue ying , ZENG Zh i ( 1. School of Chem istry and Env ironm ent, South China N orm alUniversity, Guangzhou 510631, China; 2. School of Chem istry and Chem ical Engineering, GuangzhouU niversity, Guangzhou 510402, China) Abstract: Chiral diols 1, 2, 5, 6 O diisopropalene D mannitol( III) and 1, 3, 4, 6 O dibenzaliene D mannitol( IV) and its derivativeswere synthesized and characterized, among which 1, 3, 4, 6 O di( p chlorobenzaliene) D m annitol(V) and1, 3, 4, 6 O di( p methyl benzaliene) D mannitol(V I) are new compounds. When these chiral diol ligandwere tested in asymmetric epoxidation of chalcone and cinnamyl alcohols, they all gave good catalytic activity( 97. 4% 100% conv. ), and low to moderate enantioselec tivity ( 14% 31. 7% ee). The relative sm al