维持性腹膜透析患者心血管钙化危险因素剖析.docVIP

维持性腹膜透析患者心血管钙化危险因素剖析 　　[摘要] 目的 探?维持性腹膜透析患者心血管钙化的相关危险因素。方法 方便选择该院2016年5月―2017年4月规律腹膜透析3个月以上的患者50例为研究对象，收集上述患者临床资料，评估患者冠状动脉、腹主动脉及心脏瓣膜钙化情况，根据是否出现心血管钙化分为钙化组及非钙化组，比较两组一般资料，采用Logistic回归分析法分析心血管钙化的危险因素。结果 钙化组患者26例，未钙化组24例，分析两组一般资料，钙化组年龄（56.8±6.2）岁、透析龄（36.7±4.2）个月、糖尿病史（20例）、收缩压（146.2±19.17）mmHg、脉压差（63.48±8.26）mmHg、血磷（1.78±0.23）mmol/L、残余肾功能（0.66±0.34）mL/（min?1.73 m2）、Kt/V（1.57±0.42）、肌酐清除率（47.07±6.73）L/（周?1.73 m2），与对照组差异有统计学意义（P0.05）；经Logistic回归分析，年龄、透析龄、血磷是心血管钙化的重要危险因素，Kt/V则是保护因素。 结论 维持性腹膜透析患者心血管钙化发生率高。临床上对于高龄、长透析龄、高磷血症的患者因高度重视，及时采取干预措施，降低心血管钙化的发生。 　　[关键词] 维持性腹膜透析；心血管钙化；危险因素 　　[中图分类号] R459 [文献标识码] A [文章编号] 1674-0742（2017）10（b）-0026-03 　　[Abstract] Objective This paper tries to investigate the risk factors of cardiovascular calcification in maintenance peritoneal dialysis patients. Methods 50 patients treated with regular peritoneal dialysis in this hospital for more than 3 months from May 2016 to April 2017 were convenient selected for the study. The clinical data of these patients were collected to evaluate the calcification of coronary artery， abdominalaorta and cardiac valve. And the patients were divided into the calcification group and the non-calcification group according to whether calcification was shown or not. And then the general data of the two groups were compared， and the risk factors of cardiovascular calcification were analyzed by Logistic regression analysis. Results There were 26 cases of patients in the calcification group and 24 cases in the non-calcification group. The age， dialysis vintage， diabetes mellitus history， systolic pressure， pulse pressure， serum phosphorus， residual renal function， Kt/V and creatinine clearance rate were （56.8±6.2） years old， （36.7±4.2） months， （20 cases）， （146.2±19.17） mmHg， （63.48±8.26） mmHg， （1.78±0.23） mmol/L， （0.66±0.34） mL/（min?1.73 m2）， （1.57±0.42） and （47.07±6.73） L（week?1.73 m2） in the calcification group， which were significantly different from those in the control group by analyzing the general data （P0.05）.