甲泼尼龙治疗重症急性胰腺炎疗效剖析.docVIP

甲泼尼龙治疗重症急性胰腺炎疗效剖析 　　【摘要】 目的 探讨甲泼尼龙对重症急性胰腺炎的治疗作用。方法 回顾分析辽宁医学院附属第三医院2004年1月至2007年12月收治的重症急性胰腺炎患者62例，其中常规治疗组32例（对照组），甲泼尼龙治疗组30例（治疗组）。对比两组患者腹痛、腹胀缓解时间，血、尿淀粉酶恢复正常时间，腹水消退时间，病死率，并发症发生率，住院时间等，以评价甲泼尼龙治疗重症急性胰腺炎的临床疗效。结果 治疗组腹痛、腹胀缓解时间，血、尿淀粉酶恢复正常时间，腹水消退时间，住院时间较对照组明显缩短(P0．05）。结论 甲泼尼龙对重症急性胰腺炎有明显临床疗效，能够降低病死率，减少并发症，缩短住院时间。?【关键词】 甲泼尼龙；重症急性胰腺炎；疗效?? 　　The efficacy analysis of methylprednisolone treatment of severe acute pancreatitis 　　 ZHAO Chi-long，XIE Yi-ming. Department of General Surgery ，Third Affiliated Hospital of Liaoning College of Medicine ，Liaoning 121000，China 　　? 　　【Abstract】 Objective To investigate the therapeutic effects of methylprednisolone（MP）in the treatment of the patients with severe acute pancreatitis(SAP).Methods 62 paitents with severe acute pancreatitis in our department from january 2004 to december 2007 including two groups：convention group (control group,n=32)and methylprednisolone group(treatment group, n=30) ．To reviewed analyzed and compared with the relieve time of abdominal pain abdominal distention, the regression time of abdominal dropsy,the hospital stay(day),the morbidity of complications,the case fatality,the restore time of hemodiastase ,urinary amylase.Results The relieve time of abdominal pain abdominal distention, the regression time of abdominal dropsy,the hospital stay,the restore time of hemodiastase,urinary amylase in treatment group were markedly shorter than those in control group(P0．05)． Conclusions The medicine methylprednisolone has good therapeutic effects in the treatment of the patients with SAP． It can decrease the case fatality, reduce the hospital stays and complications．? 　　【Key words】 Methylprednisolone;Severe acute pancreatitis;Therapeutic effects 　　 　　急性胰腺炎（acute pancreatitis ，AP）是外科常见的急腹症之一，发病率较高，临床上根据病情轻重分为轻型急性胰腺炎(mild acute pancreatitis，MAP)和重症急性胰腺炎（severe acute pancreatitis，SAP）。重症急性胰腺炎发病急、进展快、并发症多，占急性胰腺炎的15%～30%，死亡率为 2%～22%（平均达10%～20%）[1]，国外为10%～40%[2-3]。急性胰腺炎的病因多为胆汁反流、过量饮酒、十二指肠液反流、胰腺血循环障碍、创伤以及其他因素所致，国内以胆道疾病为主约50