芳香基亚硒酸有机锡化合物的合成、结构表征及体外抗癌活性分析-有机化学专业论文.docxVIP

聊城大学硕士学位论文 聊城大学硕士学位论文 PAGE PAGE iii ABSTRACT Since the 1950s, the studies of extensive applications in industry and agriculture such as PVC stabilizers, asymmetric synthesis, pharmaceutical chemistry and the other areas grow prosperous. The synthesis of organotin compounds having biological activity is the frontier field of organotin chemistry. Besides, organoselenium compound has drawn great attention due to their special structure, excellent performance and extensive applications recently，and organoselenium compound with high biological activity not only can be more effectively for the body to absorb, but have less toxic than inorganoselenium compound. Organoselenium medicaments which have remakeable effect on the antivirus and anticancer make significant contributions to overcome diseases for humankind. Therefore, intensive study of organotin compounds derived from areneseleninic acids has practical application potential. On the other hand, the structure and coordination model of benzeneseleninic acids are similar to carboxylic acids, organotin compounds can also exhibit complicated and interesting structures. In view of the above reasons, we selected and synthesized some benzeneseleninic acids， further synthesized a series of organotin complexes derived from areneseleninic acids, and made research of their structure and properties in detail. The research of the paper is as follows: 4-fluorobenzeneseleninic acid and 4-bromobenzeneseleninic acid were synthesized and investigated via reactions of diorganotin and triorganotin. Finally, we succeeded to get six organotin compounds, these complexes were characterized by means of IR, NMR, elemental analysis. Five complexes were also characterized by X-ray crystallographic diffraction analysis. The analysis revealed that: (1) when 4-fluorobenzeneseleninic acid or 4-bromobenzeneseleninic acid reacts with R3SnCl (R = Me, Ph) at 1:1 molar ratio, they adopt infinite 1D polymeric chain structure. 4-fluorobenzenes