单管式子宫颈癌后装施源器的疗效、安全性随机对照临床试验-肿瘤学专业论文.docx

- - PAGE 10 - The Clinical Random Control Research About Efficacy And Toxicity Of the single Tube Intracavitary Brachytherapy Applicator For Cervical Carcinoma Abstract ：Objective：Underground of phantom experiment and stage I clinical trial,to research whether the single tube intracavitary brachytherapy applicator for cervical carcinoma can attain identical clinical efficacy and similar even lower toxicity contrast with the fletcher applicator。Methods: 49 cervical carcinoma patients with different FIGO stages who need external irradiation and intracavitary brachytherapy were researched.These patients were randomly divided into external irradiation plus the single tube intracavitary brachytherapy applicator and external irradiation plus the fletcher intracavitary brachytherapy applicator. All patients were treated with a four-fields box technique or conventional two-fields technique ,when external irradiation dose arrive at 3000cGy,lead blocks was beginning,while two-fields technique external irradiration continue until pelvic dose arriving in 4800-5000cGy.After 3000cGy, intracavitary brachytherapy were following with different applicators according different groups. 192Ir was used as irradiation resource, once a week(stop a externa irradiation while intracavitary brachytherapy). A Point (the 38th report of ICRU )dose was 700cGy. Intracavitary brachytherapy was carried out 6 times（BED of A point： 9000-9200cGy）.At first Intracavitary brachytherapy, dose of the bladder reference point and rectal reference point was measured with LiF TLD and contrasted.During irradiation ,chemotherapy was used with cisplatin（40mg/m2），once a week.During treating ,the short-term efficacy and toxicity were observed.After treating,long-term efficacy and toxicity were followed up.Results: 1. The does of the bladder、rectum reference point treated by the Fletcher intracavitary brachytherapy applicator are 270±114.7cGy、360±146.4cGy respectively , The does of the bladder