四、异甘草酸镁防治药物性肝损伤研究进展2(修改版).docVIP

PAGE \* MERGEFORMAT PAGE \* MERGEFORMAT 1 异甘草酸镁防治药物性肝损伤的研究进展 摘要：药物性肝损伤(DILI)可发生在没有肝脏疾病的人群，或以往有肝脏疾病的患者使用某种药物后发生不同程度的肝损伤。这些年，随着药物种类越来越多以及新药不断出现和各类保健药物的应用，药物性肝损伤的发病率呈现出一种逐步上升的趋势。异甘草酸镁是最新一代的甘草酸制剂，在防治药物性肝损伤方面有其优势。本文通过对异甘草酸镁在抗结核药、抗肿瘤药两类药物所引起的药物性肝损伤的研究现状进行阐述与归纳总结。 关键字：异甘草酸镁；药物性肝损伤；防治 Abstract: Drug-induced liver injury (DILI) can occur in people without liver disease, or ever had liver disease patients with certain drugs after different degrees of liver damage. ?These years, as more and more kinds of drugs as well as new drugs, and new drugs appear constantly and the application of various kinds of health care medicine,?the incidence of drug-induced liver injury showing a gradual upward trend. Magnesium isoglycyrrhizinate is the latest generation of licorice acid preparations, has its advantages in prevention and treatment of drug-induced liver injury. ?In this paper, through research the status of Magnesium isoglycyrrhizinate in anti-TB drugs, antitumor drug-induced two kinds of drugs drug-induced liver injury were described and summarized by. Key words: Magnesium isoglycyrrhizinate; drug-induced liver injury; prophylaxis and treatment TOC \o 1-3 \h \z \u 目录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc419642590 摘要 PAGEREF _Toc419642592 \h II HYPERLINK \l _Toc419642592 Abstract PAGEREF _Toc419642592 \h II HYPERLINK \l _Toc419642593 HYPERLINK \l _Toc419642595 前言 3 HYPERLINK \l _Toc420326979 1 药物性肝损伤 PAGEREF _Toc420326979 \h 3 HYPERLINK \l _Toc420326980 1. 1药物性肝损伤的概念与流行病学 PAGEREF _Toc420326980 \h 3 HYPERLINK \l _Toc420326981 1. 1. 1药物性肝损伤的概念 PAGEREF _Toc420326981 \h 3 HYPERLINK \l _Toc420326982 1. 1. 2我国药物性肝损伤的流行病学 PAGEREF _Toc420326982 \h 3 HYPERLINK \l _Toc420326983 1. 2药物性肝损伤的发病机制 PAGEREF _Toc420326983 \h 4 HYPERLINK \l _Toc420326984 2 异甘草酸镁 PAGEREF _Toc420326984 \h 5 HYPERLINK \l _Toc420326985 2. 1异甘草酸镁的认识 PAGEREF _Toc420326985 \h 5 HYPERLINK \l _Toc420326986 2. 2异甘草酸镁的药理作用 PAGEREF _Toc420326986 \h 5 HYPERLINK \l _Toc420326987 3 异甘草酸镁对药物性肝损伤的防治