生物化学ii（苏维恒）代总论-20140303.pptVIP

In feedback inhibition（反馈抑制） The end product of a metabolic pathway shuts down the pathway through inhibition of an early step, usually the first committed step. Feed-forward activation（前馈激活） occurs when a metabolic produced early activates an enzyme that catalyzes a reaction further down the pathway. Active siteavailable Isoleucineused up bycell Feedbackinhibition Isoleucine binds to allosteric site Active site of enzyme 1 no longer binds threonine;pathway is switched off Initial substrate(threonine) Threoninein active site Enzyme 1(threoninedeaminase) Interme