氟尿嘧啶印迹水凝胶作为药物缓释载体的研究化学工程与技术专业论文.docx

哈尔 哈尔滨工业大学工学硕士学位论文 - - II - Abstract Hydrogel is generally used as drug carriers due to its wide resources and biocompatibility in the field of drug delivery. Meanwhile, molecular imprinting, as a increasingly developing technology, has large potential use in life sciences. Especially used in the drug delivery arena , their specific recognition sites are considered to enhance the amount of drug carried by the matrices as well as to sustain the pace of the drug release from the imprinted polymers. In this text, 5-fluorouracil was used as the template to synthesize imprinted hydrogels in aqueous and organic system respectively. In the aqueous solution, 2-hydroxyethylmetacrylate was used as the main component, methacrylic acid as the functional monomer, ethyleneglycol dimethacrylate as the crosslinker and ammonium persulfate as the initiator. However, in organic phase, 2-hydroxyethylmetacrylate was used as the backbone monomer, methacrylic acid as the functional monomer, ethyleneglycol dimethacrylate as the crosslinker and 2,2’-azoisobutyronitrile as the initiator. Tests of drug loading capacity showed that the hydrogels synthesized in aqueous solution were unable to load drug, while those synthesized in organic phase were capable to.bind. Experiments of different functional monomer- template molar ratio of 16：1,8：1,4：1 and non-imprinted hydrogel to load 5-fluorouracil showed that when the functional monomer- template molar ratio was 8：1, imprinted hydrogel loaded more drug than the others did, which amounted to 0.0914mg/g.Meanwhile the amount of 5-fluorouracil loaded on the hydrogel increased with its increasing concentration in the surrounding environment, while the difference between imprinting and non-imprinted hydrogels, loading amount decreased. Tests on the drug release behavior of the hydrogels in stimulated biological fluids indicated that all the imprinted hydrogels controlled the drug release better than the non-imprinting ones, and hydrogels whos