血清CA724、CA199检测联合全身骨显像在胃癌骨转移中的诊断价值.docVIP

血清CA72-4、CA19-9检测联合全身骨显像在胃癌骨转移中的诊断价值 路宝士(通信 )赵立明(临沂市人民医院核医学科山东临沂276003) 屮图分类号】R735.2 】A 】1672-5085 (2013) 27-0109-02 】R的评价血淸肿瘤标志物糖类抗原72-4 (CA72-4)、糖类抗原19-9 (CA19-9)检测联合全身骨显像在H癌骨转移诊断屮的价值。方法对97例胃癌患 者(其屮，骨转移者34例、无骨转移者63例)及54例良性胃部疾病患者(对照 组)行SPECT全身骨显像和CT或MRI检查，同时，用电化学发光法测定其血淸 CA72-4、CA19-9含量，并将两者的结果进行比较。结果骨转移组CA72-4、CA19-9 水平明显高于无骨转移组和对照组，其诊断阳性率分别为75.29%、62.43%,骨 转移组全身骨显像32例为阳性(占94.12%)，仅2例为阴性(占5.88%),但CT 或MRI发现转移；无骨转移组及对照组骨显像个别为阳性，均由手术或外伤引 起。结论CA72-4、CA19-9检测联合全身骨显像有助于提高胃癌骨转移的检出率。 关键词】全身骨显像血淸肿瘤标志物胃癌骨转移 The value of combined examination of serum CA72-4,CA19-9 level and whole body bone scan in the diagnosis of bone metastasis in gastric cancer LU Bao-shi, ZHAO Li-ming( Department of Nuclear Medicine, The Peoplersquo;Hospital of Linyi, Linyi 276003, China) Abstract】 Objective To explore the value of combined examination of serum tumormarkers carbohydrate antigen 72-4 (CA72-4), carbohydrate antigenl9-9 (CA19-9) and whole body bone scan in the diagnosis of bone metastasis in gastric cancer. Methods Whole body bone scan,CT or MRI, serum CA72-4 and CA19-9 levels with a chemical luminiferous determination were performed in 97 patients with gastric cancer (34 cases with bone metastasis and 63 cases without bone metastasis) and 54 patients with benign gastric diseases. Results The serum level of CA72-4 and CA19-9 were significantly higher in patients with bone metastasis than those in patients without bone metastasis and the controls. The positive predicting values were 75.29%, 62.43%. Most patients with bone metastasis had positive results in bone scan（94.12%） , only 2 cases had negative results （5.88%） , which is positive by CT or MRI. A few patients without bone metastasis and the controls had positive results in bone scan, that may be caused by previous operation or injury. Conclusion The combined examination of CA72-4,CA19-9 and whole body bone scan were valuable in the diagnosis of bone metastasis of gastric cancer. Key words］ whole body bone scan serum tumormarke