DTI脑连接组分析中分割模板的选择.pdfVIP

第44卷 第4期 北 京 工 业 大 学 学 报 Vol.44 No.4 2018年 4月 JOURNAL OF BEIJING UNIVERSITY OFTECHNOLOGY Apr. 2018 DTI脑连接组分析中分割模板的选择 林摇 岚,张柏雯,靳摇 聪,吴水才 (北京工业大学生命科学与生物工程学院,北京摇 100124) 摘摇 要:由于脑网络性质会因网络构建方法不同(如脑区划分模板、弥散磁共振成像(magnetic resonance imaging, MRI)模型、纤维素追踪算法和网络加权方案等)而出现较大的差异,针对弥散张量成像(diffusion tensor imaging, DTI),基于临床研究中的典型设置,研究了不同分割模板对脑网络拓扑参数的影响. 参与本研究的75例健康老年 人均接受了相同的认知功能综合评估和同一3T磁共振采集系统的全脑扫描. 结果显示全局拓扑属性对脑区划分 的空间尺度非常敏感,而对脑区划分原则并不是特别敏感. 脑网络的模块化结构相对较稳定,不易受到节点划分尺 度和节点划分原则的影响. 中等分辨率的模板在大脑老化分析中具有更高的敏感性,可能更适合于常规DTI脑网 络分析. 关键词:分割模板;弥散张量成像(DTI);脑连接组 中图分类号:R445郾2 文献标志码:A 文章编号:0254-0037(2018)04-0617-10 doi:10.11936/ bjutxb2017020037 Selection of Parcellation Atlas in DTI Brain Connectome Analysis LIN Lan,ZHANG Baiwen,JIN Cong,WU Shuicai (College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China) Abstract:Analysis of the structural connectomes based on diffusion magnetic resonance imaging (MRI) can show network attributesfor segregation and integration in the human brain. However,it is reported that there are large discrepancies from those network measures, which may result from the network construction methodology (such as brain parcellations,DWI acquisition model,tractography algorithms and network weighting schemes). The influence of parcellation atlason the topological network measures of diffusiontensor imaging (DTI)networkwiththetypical settingusedinmany clinical applicationswere evaluated in this paper. The data of research were acquired in 75 healthy older adults who underwent several neuropsychological tests and structural MRI. It shows that those network measures are