风血宁口服液对脑出血急性期纤维蛋白原及肾素活性、血管紧张素ⅱ的影响.docVIP

风血宁口服液对脑出血急性期纤维蛋白原及肾素活性、血管紧张素Ⅱ的影响 【摘要】 目的 探讨风血宁口服液对脑出血急性期纤维蛋白原（FIB）及肾素活性（PRA）、血管紧张素Ⅱ (AngⅡ)的影响。方法 将80例脑出血急性期患者随机分为2组，对照组40例予常规脱水降颅压、减轻脑水肿及支持疗法。治疗组40例在对照组治疗基础上予风血宁口服液，每次150 mL，每日2次口服。观察风血宁口服液对脑出血急性期FIB及PRA、AngⅡ的影响。结果 风血宁口服液治疗后3日、8日FIB及PRA、AngⅡ与对照组比较差异均有统计学意义(Plt;0.05)。结论 风血宁口服液能加速脑出血急性期患者FIB的降解和AngⅡ的降低，激活内源性的纤溶活性，改善微循环，有助于血肿的液化吸收，从而促进神经功能的恢复。 【关键词】 脑出血；急性病；中药疗法；纤维蛋白原；肾素；血管紧张素Ⅱ 　　【Abstract】 Objective To investigate the effect of Fengxuening oral liquid on fibrinogen(FIB), prorenin activity (PRA) and angiotension Ⅱ (AngⅡ) in patients with cerebral hemorrhage at acute period. Methods 80 patients with cerebral hemorrhage at acute period were randomly divided into two groups.40 patients in control group were treated by routine dehydration, reducing intracranial pressure, relieving encephaledema and supporting therapy,however the other 40 patients in treatment group, on the basis of control group, were treated by Fengxuening oral liquid,150 mL once,twice a day. The FIB,PRA and AngⅡwere detected and compared in the two groups. Results There were significant differences in FIB,PRA and AngⅡ at the 3rd and 8th after administration with Fengxuening oral liquid, as compared with those in control group(Plt;0.05). Conclusion For patients with cerebral hemorrhage at acute period Fengxuening oral liquid can promote the degradation of FIB and reduce AngⅡ, activate endogenous fibrinolytic activity, improve micro circulation, promote the absorption of hematoma, as a result, promote the recovery of patients nervous function. 　　【Key words】 Cerebral hemorrhage;Acute diseases;TCM therapy；Fibrinogen, Prorenin; Angiotension Ⅱ 　　脑出血系指非外伤性脑实质内的出血。脑出血后引起机体和脑组织局部一系列病理性反应,其中最重要的是脑内血肿、血肿分解产物和脑组织直接损伤释放出的血管活性物质所致的脑水肿、局部脑血流量降低、凝血纤溶系统变化及颅内压增高等，这些变化严重影响了脑出血预后。风血宁口服液为我院研制的治疗脑出血急性期的中药。2004-07—2007-05，我们采用风血宁口服液治疗脑出血急性期40例，观察其对纤维蛋白原（FIB）及肾素活性（PRA）、血管紧张素Ⅱ (AngⅡ)的影响，现报告如下。 　　1 资料与方法 　　1.1 病例入选标准 全部病例均参照《神经病学》［1］确定诊断。①45～75岁；②临床表现为卒中综合征；③经CT证实为脑出血；④无昏迷、昏睡等严重意识障碍；⑤有严重肢体瘫痪或无瘫