高-低氧放射治疗中晚期子宫颈癌的Ⅰ期临床观察-肿瘤学专业论文.docxVIP

高一低氧放射治疗中晚期子宫颈癌的I期临床观察 高一低氧放射治疗中晚期子宫颈癌的I期临床观察 摘 要 【目的】通过对中晚期宫颈癌患者进行高一低氧耐力试验及高一低氧放疗和单纯放疗 的对比临床研究观察，初步评价高一低氧放疗治疗中晚期宫颈癌的近期疗效及副反 应。 【方法】54例中晚期宫颈癌患者随机分成高一低氧放疗组(26例)和单纯放疗组(28 例)。高一低氧放疗组在外照射放疗前先吸入5分钟高氧(95％氧气；0n5％-氧化碳的混 合气体)立即改吸含氧体积分数为0．105的低氧气体1分钟后开始放疗，直至放疗结 束停止吸气，吸入低氧5分钟内完成放疗。单纯放疗组仅行单纯放疗，两组放疗方案 相同。 【结果】高一低氧放疗组与单纯放疗组的半程疗效(完全缓解率+部分缓解率)分别是 53．8％和39．3％，差异无统计学意义(H=一1．062，PO．05)。高一低氧放疗组与单纯放 疗组全程放疗后有效率均为100％，完全缓解率分别是61．5％和50．0％，差异无统计学 意义(H一0．800，PO．05)。高一低氧放疗组的消化道反应较单纯放疗组轻，差别有 显著意义(H=一2．565，PO．05)；骨髓抑制如白细胞及中性粒细胞下降程度较单纯 放疗组轻，差异有显著意义(H一2．004，-2．441，PO．05)。其他反应如皮肤反应、 急性膀胱反应及血小板下降无显著差异。 【结论】与常规放疗比较，高～低氧放疗有可能提高中晚期宫颈癌的近期疗效，提 高肿瘤组织对放疗的敏感性，同时不提高或降低中晚期宫颈癌的放疗副反应，对正 常组织有一定的放射防护作用，是通过非物理手段提高中晚期宫颈癌放射治疗增益 比的可选择手段。 硕士研究生： 于兰(肿瘤学) 指导教师： 安永恒 教授 关键词：宫颈肿瘤／放射治疗；疗效；副作用 The The stage I clinical trial of carbogen plus low concentration oxygen radiotherapy for advanced cervical carcinoma Abstract Objective：To evaluate the short——term efficacy and side effects of carbogen plus low concentration oxygen radiotherapy(CPLCOR)for Medium—term and advanced cerv i cal carc i noma． Methods： 54 patients of medium～term and advanced cervical carcinoma were randomly divided into CPLCOR group(n=26)and radiation group(n=28)．CPLCOR group inhaled carbogen for five minutes before the start of radiotherapy and then inhaled 10．5％oxygen for one minute till the end of radiotherapy． Radiotherapy was completed in five minutes．The patients of radiotherapy group were only received radiotherapy and all patients under went the same rad iotherapy． Results：The response of half dosage in the CPLCOR group and the radiation group were 53．8％and 39．3％，respectively(H=一1．062，PO．05)．The CR rate after treatment were 61．5％and 50．0％，respectively(H=一0．800，P0．05)．The leukopenia and diarrhea decrease in CPLCOR group． Conclusion：CPLCOR may improve short—term efficacy and radi otherapy sensibility of Medium-term and advanced cervical carcinoma and not increase the side effects．CPLCOR iS one of effective measure to increase ratio of therapy．