Chapter 23虫媒病毒和出血热病毒Arbovirus Hemorrhagic Fever Virus.pptxVIP

Chapter 23虫媒病毒和出血热病毒Arbovirus Hemorrhagic Fever Virus.pptx

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Chapter23虫媒病毒和出血热病毒Arbovirus

Chapter 23 Arbovirus Hemorrhagic Fever Virus虫媒病毒和出血热病毒第一课件网网站 / Arbovirus一群节肢动物媒介病毒 p302表Arbovirus of prevalence in China ---classified as Flavivirus主要有流行性乙型脑炎病毒、登革病毒和森林脑炎病毒 Common characteristics?Small spherical particle(40-70nm), +ssRNA, icosahedral nucleocapsid, envelope and spike ?Feature of diseases caused by Arbovirus?arthropod----both vector and reservoir hosts of virus ?transmitted by bite of arthropod ?obvious season and district ?clinical manifestations (发热、脑炎、出血热)节肢动物既是传播 媒介又是储存宿主 Encephalitis B Virus乙型脑炎病毒 ? also called Japanese encephalitis virus(JEV)? the most common cause of epidemic encephalitis1. Biological Properties ? Typical flavivirus both in structure and in shape ? Structural protein:C,M and E protein(hemagglutinin)+ss-RNA能凝集雏鸡、鸽和鹅的红细胞(PH6.0) (球形、单正链RNA 、 20面体对称的包膜病毒) ? Cultivation?suckling mice? embryo-eggs? cell culture(C6/36 cell) ? Antigenicity(single and stable) 2.Pathogenicity and Immunity ? Natural cycles of JEV 蚊→动物→蚊bite mosquito domestic animal or birds domestic animal mosquito or birds (young pigs)(culex) ova (viremia) 病毒血症bitebitehuman? vector of transmission and reservoir? source of infection? route of transmission---三节吻库蚊 蠛蠓 ,蝙蝠---幼猪? epidemic season and district ? JEV-infection(neurotropic virus→infection of CNS)? Asymptomatic infection? Abortive infection? Cause epidemic encephalitis B (0.1%)? Immunity(IgM→IgG)---long-lasting immunity3.Laboratory Diagnosis ? Isolation of virus (cell culture) ? Serological diagnosis ---detection of specific IgM by antibody cupture-ELISA (ACELISA)急性期阳性率90%4. Prevention? Cut off the route of transmission? Artificial active immunity? Vaccination of the young pigs(vector control)(inoculate live or killed vaccines) Dengue virus登革病毒(pathogen of dengue fever) 1.Biological properties ?Shape and structure(similar to JEV) ?Cultivation ?4 serotypes (各型间有交叉)(C6/36细胞培养,乳鼠接种)2. Pathogenicity ?Natural cycle of virus ? human(monkey)→mosquitoes→Human (monkey)? vector---- aedes? source of infec

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