CDC25B小分子抑制剂的发现及评价-分析化学专毕业论文.docxVIP

Discovery and characterization of novel CDC25B inhibitors Cell division cycle 25(CDC25)phosphatases regulate key transitions between cell cycle phases during normal cell division by dephosphorylating and activating the CDK(cyclin-dependent kinase)complexes．And in the event of DNA damage they are the targets of the checkpoint machinery that ensures genetic stability．Since then，CDC25 was reported to be overexpressed in primary tissue samples from various human cancers．Some evidences suggested that the overexpression of CDC25 may contribute to Cancel And down—regulation of CDC25 caused cell cycl