血脂治疗进展赵水平.pptVIP

A vicious cycle of vascular inflammation with recurrent injury results in the formation of a necrotic core and eventually vulnerable plaque. The initial step is entry and entrapment of LDL within the arterial wall, followed by entry of monocytes that take up the LDL and become foam cells. Crystals in the foam cells induce apoptosis, leading to further attraction of macrophages that forms an extracellular lipid pool within the arterial wall. This then constitutes the basic elements of a vulnerable plaque. * Mechanism of plaque rupture and/or erosion induced by cholesterol crystallization. In t