骨代谢标志物的临床应用.pptVIP

* * The picture shows a simplified metabolism of Vit D. Ultraviolet-light of wavelenght 290 – 320 nm converts 7-Dehydrocholesterol into Cholecalciferol (D3) in the skin. In this way constituted Vitamin D3 - or Vit D3 uptaken by nutrition- is - attached to a Vitamin D binding protein – transported to the liver. There the first of two hydroxylations takes place. 25-OH Vitamin D attains the kidney, where in a second hydroxylation step the biological active 1, 25 Dihydroxy-Vitamin D3 is built. The precursor 25-OH Vitamin D is circulating in the blood in a thousand times higher concentration comp