主要ABO血型不合异基因造血干细胞移植后纯红细胞再生障碍.PDFVIP

( ) 中国实验血液学杂志　Journal of Experimental Hem atology 2002 ; 10 1 :61 - 65 ·61 · Pure Red Cell Aplasia Following Major ABOIncompatible Allogeneic Hematopoietic Stem Cell Transplantation ZHU KangEr ,XU Yang ,WU Dong ,ZHON G J uan ( ) The First Af f iliated Hospital , Medical College of Jinan U niversity , Guangz hou 510630 Abstract 　　Six out of 20 patients undergoing a major ABOincompatible allogeneic stem cell transplantation ( allo HSCT) developed pure red cell aplasia( PRCA) , which did not showany effects on granulocyte and platelet engraftment , and incidence of grade Ⅱ- Ⅳa GVHD. All the 6 cases of PRCA were in blood group O recipients of grafts from blood group A donors( n = 5) or blood group B donor( n = 1) , suggesting that donor/ recipient pair( A/ O) is associated with a high risk of PRCA after major ABOincompatible alloHSCT. Erythroid engraftment occurred spontaneously in four cases without specif ic intervention other than the RBC transfusion , which coincided with the decrease of isoagglutinin titers below 8 , and the remaining 2 patients with prolonged erythroid aplasia ( 300 days) despite therapy with erythropoietin( EPO) were successfully treated by plasma exchange with donortype plasma replacement. Cyclosporine did not appear to have played any role in causing PRCA in our patients , however , the occurrence of GVHD may facilitate the recovery of erythropoiesis. Key words 　　pure red cell