文献名中文氙不会延长无心血管疾病病人及志愿者的QTc.PDF

氙不会延长无心血管疾病病人及志愿者的 QTc 贵州医科大学麻醉学系研究生（心电生理及记忆课题组） 文献名：（中文） 氙不会延长无心血管疾病病人 及志愿者的 QTc （英文）Xenon Does Not Increase Heart Rate –corrected Cardiac QT Interval in Volunteers and in Patients Free of Cardiovascular Disease 译 者：雷涓 原文摘要：Abstract Background:: Impaired cardiac repolarization, indicated by prolonged QT interval, may cause critical ventricular arrhythmias. Many anesthetics increase the QT interval by blockade of rapidly acting potassium rectifier channels. Although xenon does not affect these channels in isolated cardiomyocytes, the authors hypothesized that xenon increases the QT interval by direct and/or indirect sympathomimetic effects. Thus, the authors tested the hypothesis that xenon alters the heart rate –corrected cardiac QT (QTc) interval in anesthetic concentrations. Methods:: The effect of xenon on the QTc interval was evaluated in eight healthy volunteers and in 35 patients undergoing abdominal or trauma surgery. The QTc interval was recorded on subjects in awake state, after their denitrogenation, and during xenon monoanesthesia (FetXe 0.65). In patients, the QTc interval was recorded while awake, after anesthesia induction with propofol and remifentanil, and during steady state of xenon/remifentanil anesthesia (FetXe 0.65). The QTc interval was determined from three consecutive cardiac intervals on electrocardiogram printouts in a blinded manner and corrected with Bazett formula. Results:: In healthy volunteers, xenon did not alter the QTc interval (mean difference: +0.11 ms [95% CI, −22.4 to 22.7]). In patients, after anesthesia induction with propofol/remifentanil, no alteration of QTc interval was noted. After propofol was replaced with xenon, the QTc interval remained unaffected (417 ± 32 ms vs. awake: 414 ± 25 ms) with a mean difference of 4.4 ms (95% CI, −4.6 to 13.5). Conclusion:: Xenon monoanesthesia in healthy volunteers and xenon/remifentanil anesthesi