含单氟甲氧基的双酰胺类化合物的合成及杀虫活性.PDFVIP

农药学学报 2018, 20(6): 715-720 Chinese Journal of Pesticide Science • 研究论文 • DOI: 10.16801/j.issn.1008-7303.2018.0090 含单氟甲氧基的双酰胺类化合物的合成及杀虫活性 张冬林, 杨 森, 杨 忍, 裴 丹, 张 帆, 刘 杰, 李建业, 谭成侠* (浙江工业大学 化学工程学院，杭州 310004) 摘 要：以2,3-二氯吡啶为起始原料，经肼基化、环合、氧化、取代、水解、环合和胺解反 应，合成了15 个文献未见报道的新型含单氟甲氧基的吡唑邻甲酰氨基苯甲酰胺类化合物，其 结构通过核磁共振氢谱和高分辨质谱确认。初步的杀虫活性测试结果显示，所有目标化合物在 100 mg/L 下对粘虫Oriental armyworm 的致死率均为100%，当测试浓度降低至4 mg/L 时，化 合物8a 、8d 、8g 、8k 和8n 的致死率仍为100%，值得进一步研究。 关键词: 新农药创制；单氟甲氧基；双酰胺类杀虫剂；吡唑；杀虫活性 中图分类号：O626 ；TQ453.2 文献标志码：A 文章编号：1008-7303(2018)06-0715-06 Synthesis and insecticidal activities of diamides containing monofluoromethoxy group ZHANG Donglin, YANG Sen, YANG Ren, PEI Dan, ZHANG Fan, LIU Jie, LI Jianye, TAN Chengxia* (College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310004, China) Abstract: Fifteen novel diamides containing monofluoro methoxy group compounds were synthesized using 2,3-dichloropyridine as the starting material by hydrazinolysis, cyclization, oxidation, substitution, hydrolysis, cyclization and amine hydrolysis. The structures of the title compounds were 1 characterized by H NMR and HRMS. Preliminary bioassay results indicated that all the target compounds showed insecticidal activities. At the concentration of 100 mg/L, all compounds exhibited 100% insecticidal activities a