癃闭舒胶囊联合罗红霉素治疗慢性前列腺炎的临床研究.PDFVIP

·2352 · 现代药物与临床 Drugs Clinic 第 33 卷 第 9 期 2018 年 9 月 癃闭舒胶囊联合罗红霉素治疗慢性前列腺炎的临床研究 宋瑞彬，刘琛琛，董山峰，孙国庆，郑保良，崔自刚，赵永体 焦作煤业（集团）有限责任公司中央医院 泌尿外科，河南 焦作 454000 摘 要：目的 观察癃闭舒胶囊联合罗红霉素治疗慢性前列腺炎的临床疗效。方法 选取 2016 年 7 月—2017 年 6 月在焦作 煤业（集团）有限责任公司中央医院治疗的慢性前列腺炎患者 106 例，随机分为对照组和治疗组，每组各 53 例。对照组患 者口服罗红霉素胶囊，150 mg/次，2 次/d ；治疗组在对照组基础上口服癃闭舒胶囊，3 粒/次，2 次/d 。两组患者均治疗4 周。 观察两组患者临床疗效，同时比较治疗前后两组患者肿瘤坏死因子-α （TNF-α）和白细胞介素-6 （IL-6 ）水平及慢性前列腺 炎症状指数（NIH-CPSI ）评分。结果 治疗后，对照组临床总有效率为 77.36%，显著低于治疗组的 92.45%，两组比较差异 具有统计学意义（P ＜0.05 ）。治疗后，两组血清和前列腺液中 TNF-α和 IL-6 水平及 NIH-CPSI 评分均显著降低，同组比较 差异具有统计学意义（P ＜0.05 ）；且治疗组患者上述指标水平明显低于对照组，两组比较差异具有统计学意义（P ＜0.05 ）。 结论 癃闭舒胶囊联合罗红霉素治疗慢性前列腺炎临床疗效确切，具有一定的临床推广应用价值。 关键词：癃闭舒胶囊；罗红霉素胶囊；前列腺炎；临床疗效；肿瘤坏死因子-α；慢性前列腺炎症状指数 中图分类号：R914 文献标志码：A 文章编号：1674 - 5515(2018)09 - 2352 - 04 DOI: 10.7501/j.issn.1674-5515.2018.09.043 Clinical study on Longbishu Capsules combined with roxithromycin in treatment of chronic prostatitis SONG Rui-bin, LIU Chen-chen, DONG Shan-feng, SUN Guo-qing, ZHENG Bao-liang, Cui Zi-gang, ZHAO Yong-ti Department of Urology Surgery, Jiaozuo Coal Industry Group Central Hospital, Jiaozuo 454000, China Abstract: Objective To observe the clinical effect of Longbishu Capsules combined with roxithromycin in treatment of chronic prostatitis. Methods Patients (106 cases) with chronic prostatitis in Jiaozuo Coal Industry Group Central Hospital from July 2016 to June 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Roxithromycin Capsules, 150 mg/time, twice daily. Patients in the treatment group were po administered with Longbishu Capsules on the basis of the control group, 3 grains/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the TNF-