替莫唑胺同期全脑放疗治疗脑转移瘤的疗效观察.pdfVIP

山西医科大学硕士学位论文 6例；单纯全脑放射性治疗组治疗有效率为54.17%，其中有3例完全缓解，统计值 P0.05提示两组间差别有意义。AB 两组患者的生存率分别为56.25%和29.17%， p0.05提示有差异。 结论： 转移性脑瘤患者使用替莫唑胺联合全脑放射治疗 （A组）的毒副反应与单纯放射 治疗 （B组）相比，只有在白细胞计数中两组间差异，p0.05提示有意义，但患者可 耐受。A组的近期疗效优于B组，同时A组与B组相比显著提高了患者的1年生 率。 关键词: 替莫唑胺；同期放化疗；脑转移瘤；全脑放疗 II 山西医科大学硕士学位论文 Temozolomideperiodwholebrainradiotherapyefficacyinthe treatmentofbrainmetastases Abstract Objective: By observing oral temozolomide synchronized whole brain radiotherapy is not sequential chemotherapy treatment efficacy and toxicity of brain metastases.Analyzed using statistical methods t put nearly synchronous brain metastases after chemotherapy are not long-term efficacy of sequential chemotherapy and toxicity.Brain metastases are summarizedsuitableindividualizedtreatmentplan. Methods: Collected in January 2011 t December 2013 at the Second Affiliated Hospital of ShanxiMedical treatment met the inclusion and exclusion criteria, 40patients with brain metastases.These medical records collected detailed statistical analysis.According t the different treatment methods sufferers would be divided int temozolomide concurrent chemoradiotherapy group (group A) and radiotherapy group (group B).Tw groups of sufferers were performed linac 6mV-X line of whole brain radiation therapy. T whole brain radiation therapy methods:from the left andright side irradiated the same center of thewholebrain,DT30Gy/10,5times/week.Agroupofpatientsgivenorallyduringthesame period in the whole brain radiotherapy with temozolomide 75mg / (m ·d) chemotherapy,2 fortaking 14d,untiltheendofradiotherapy. Results: Temozolomidesameperiod 16casesofwholebrainradiotherapygroup,including 12 males and4 females, aged 38-70years old (54.94±2.39);radiotherapy 24 cases, including