哈佛幻灯：CT影像组学预测非小细胞肺癌临床结果.pdfVIP

CT based radiomic features as predictors for clinical outcomes of NSCLC Thibaud Coroller, Patrick Grossmann, Emmanuel Rios Velazquez, Raymond Mak, Hugo Aerts Dana Farber/ Brigham and Women’s - Cancer Center Harvard Medical School Science Council Session – The Physics of Cancers AAPM 56th annual meeting, July 23rd 2014 Radiomics • Medical imaging captures tumor phenotypic differences • Radiomics quantify these differences using a large set of image features1 • Quantitative radiomics data can be linked with clinical and genomic information2 • Currently only simple metrics based on tumor size are routinely quantified for clinical purpose 1. Lambin P, Rios-Velazquez E, Leijenaar R, et al. Radiomics: Extracting more information from medical images using advanced feature analysis. Eur. J. Cancer. 2012;48(4):441–446. 2. Aerts HJWL, Velazquez ER, Leijenaar RTH, et al. Decoding CT based radiomic features as predictors for clinical outcomes of NSCLC tumour phenotype by noninvasive imaging using a quantitative Thibaud Coroller radiomics approach. Nat. Commun. 2014;5. Study design Aim 1. Ability of the radiomics to predict distant metastasis 2. Distinguish better predictors than clinically used ones to detect patients at risk Data • 182