自噬与代谢及代谢性疾病-中国细胞生物学学报.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(2): 249–255 DOI: 10.11844/cjcb.2015.02.0259 自噬与代谢及代谢性疾病 陈燕锋 曾群力* (浙江大学医学院, 浙江省生物电磁学重点研究实验室, 杭州 310058) 摘要 细胞自噬是真核生物中一种高度保守的代谢过程, 可以清除受损的细胞器, 降解糖 原、脂类、蛋白质等生物大分子物质供细胞重新利用, 对维持细胞内代谢平衡有重要意义。自噬 障碍常被发现与代谢性疾病相关, 如酸性麦芽糖酶缺乏症、肥胖和神经退行性疾病等。该文就近 报 年来关于自噬与代谢及代谢性疾病的研究作一综述。 关键词 自噬; 代谢; 代谢性疾病 Autophagy, Metabolism and Metabolic Diseases 学 Chen Yanfeng, Zeng Qunli* (Bioelectromagnetics Laboratory of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310058, China) 学 Abstract Autophagy is a highly-conserved metabolic process in eukaryotes. It serves to clear damaged organelles, degrade glycogen, lipids and protein for cellular metabolic reuse, and it plays an important role in the homeostasis of cellular metabolism. Autophagic dysfunctions are often found to be involved in metabolic diseases, 物 such as Pompe disease, obesity and neurodegenerative diseases. Here we reviewed the studies on the relationship about autophagy, metabolism and metabolic diseases in recent years. Keywords autophagy; metabolism; metabolic diseases 生 ” 代谢性疾病是由于营养摄入水平改变, 能量存 eating (细胞内的物质成分利用溶酶体被降解) 的现 [6-7] 储、释放或耗散异常, 细胞信号调节障碍, 激素水平 象后将其命名为自噬, 为真核细胞所特有 。根据 [1] 紊乱或基因突