内质网应激与非酒精性脂肪肝病的研究进展-食品安全质量检测学报.PDF

4 4 Vol. 4 No. 4 2013 8 Journal of Food Safety and Quality Aug. , 2013 n-3 袁发浒, 赵秀举, 刘志国* (, 430023) 摘 要: (nonalcoholic fatty liver disease, NAFLD), , (endoplasmic reticulum stress, ERS), NAFLD , () ERS NAFLD , , n-3 (n-3 polyunsaturated fatty acids, n-3 PUFA) NAFLD NAFLD , n-3 NAFLD 关键词: n-3 ; ; ; Research progress of n-3 polyunsaturated fatty acids and the endoplasmic re- ticulum stress in non-alcoholic fatty liver disease * YUAN Fa-Hu, ZHAO Xiu-Ju, LIU Zhi-Guo (School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China) ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem. The underly- ing causes of NAFLD are unclear. Endoplasmic reticulum is the main site of protein processing, lipid synthesis and storage of calcium. Disruption of Endoplasmic reticulum homeostasis, which often induces endoplasmic reticulum stress (ERS), plays an important regulatory role in lipid metabolism and cell function. Recent evi- dence implicated the ERS in both the development of steatosis and progression to nonalcoholic steatohepatitis. In the current review