晚期结肠直肠癌进展讲义.pdfVIP

癌症 《 》 , , (): ChineseJournalofCancer2008 276 661-666 661 综 述 · · 晚期结直肠癌化疗的研究进展 , , 徐瑞华 12, 邱妙珍 12 ProgressioninPalliativeChemotherapyforAdvancedColorectalCancer , , 12 12 , XURui-Hua QIUMiao-Zhen [ ] ABSTRACT Duetotherapiddevelopmentincytotoxicagentsand , moleculartargetdrugs theresponserateofadvancedcolorectalcancer , patientshasbeenelevated andtheoverallsurvivalhasbeenprolonged. Someclinicaltrialsevenleadthemediansurvivalbeyond2years.Thisarticle focusedonthefollowingissues: comparingsingleagentchemotherapyand , combined chemotherapy comparing differentcombined chemotherapy , ( ) regimens exploringthepossibilityofreplacing5-fluorouracil 5-FU with , , capecitabine introducingthestop-and-goconception andanalyzingthe , , rolesthatmoleculartargetagents includingBevacizumabandErbitux have taken.Theelucidationofaboveissuesrevealedthattheefficacyofcombined chemotherapyonadvancedcolorectalcarcinomai