大动脉粥样硬化型缺血性卒中易感基因研究进展.PDFVIP

中国现代神经疾病杂志 年 月第 卷第 期 4 ·278 · 2018 4 18 4 Chin J Contemp Neurol Neurosurg, April 2018, Vol. 18, No. 综述 · · 大动脉粥样硬化型缺血性卒中易感基因研究进展 刘兰 王为珍 王乔树 【摘要】 脑卒中是严重威胁人类健康的疾病之一，具有高发病率、高病残率和高病死率等特点。遗 传因素在脑卒中发病中发挥重要作用，动脉粥样硬化、高血压、糖尿病、高脂血症和心脏病等是脑卒中的 危险因素，均与遗传因素相关。脑卒中易感基因是目前国内外研究的热点之一，本文拟就大动脉粥样硬 化型缺血性卒中易感基因研究进展进行综述。 【关键词】 卒中； 脑缺血； 动脉粥样硬化； 基因； 综述 Research progress of susceptibility genes associated with large artery atherosclerotic ischemicstroke 1 2 1 LIU Lan , WANG Wei⁃zhen , WANG Qiao⁃shu 1Department of Neurology, 2International Medical Care Center, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China Corresponding author: WANG Qiao shu (Email: qwang624@139.com) ⁃ 【 】 Abstract Stroke is one of the serious threats to human health, with high incidence, morbidity and mortality. Studies have shown that genes play an important role in the pathogenesis of stroke. Atherosclerosis, hypertension, diabetes, hyperlipidemia and heart disease are risk factors for stroke, and are associated with inheritance. Stroke susceptibility gene is one of the hotspots at home and abroad. This article reviews the progress of susceptibility genes in large artery atherosclerotic ischemic stroke. 【 】 Keywords Stroke; Brain ischemia; Atherosclerosis; Genes; Review This study was supported by the National Natural Science Foundation of China (No. . 脑卒中是严重威胁人类健康的疾病之一，居全 是以脂质代谢障碍、血管内皮细胞功能障碍、炎性