ph响应性两亲性嵌段共聚物的制备及胶束行为研究高分子化学与物理专业论文.docxVIP

AbstractAbStraCt Abstract AbStraCt P01ymeric mjcelles drug deliVery system白r camer廿．eatnlem llaVe receiVed great attentiOn ifl recent years．It o艉rs numerous adVamages，such increased aqueo us lub i1 ity f the drug enI】anced therapy and red uced∞rma ltissue toxicity．NowadayS，most of the polymeric micelles lJtilized t0 colls仃uct polymeric micelles made of linear amph酗hilic polymerS．Cornpared with linear polymers， me multjarm star polymers haVe attmcted atcention iIl drug deliVery印plications because they haVe m玎ow n101ecular we ight diS仃ibmjon and low solutbn Viscos咄In addition，their couH em印sulate dru黟，and the sur丘屺e gro叩s could be uSed for dmg co巧ugation labelillg．In thiS p印e rbased p01y(ethylene glyc01)(PEG)，a polymer with excellent biOcoⅡ驴atmility，、Ⅳas used to伍bricate series ofaⅡ驴hiphilic staI’b Jock copolymers with difrerent hydrophobic len百h；the se睢assembly characteriStics，印plicatiDn drug enc叩suhtbn a11d release硒m tl】ese copolymerS were inVestigated．The research contents ofthis project访clude： (1)By using liVing anionic ring opening polymerizatiOn(AItOP)of ethy|ene oxide (EO)and ethoxy ethyl 91ycidyl ether(EEGE)，a serjes of anph驴hilic star block copolyn℃rs poly(ethylem glyc01)-bbck-p01)，(ethoxy ethyl glyciClyl ether) (PEG-b—PEEGE)PEO-6-PEEGE with DPMK i11itiator and pen切【erythrito l the core．The copolymers with diffbrent hydrophobic len辔h were obtamed by changmg the凳ed rati0 of the monomer．The products were character讫ed using nuclear magnetic resomnce spectroscopy(1H．NMR)and gel permeation chronnto鲫hy (GPC)。 The self-assembly chamcteristics of PEG-6-PEEGE was detected by fluorescence-probe technique，dymmic light scattemg(DLS)and仃aI】Smission electron microscopy(TEM)． The resultS showed that the critical aggregatbn concen仃ation(CAC)values decreased with increase iIl hydrophobic chain len酉h The DLS and TEM results showed that these copolymers could self．assemble i11 aqueouS solution to南rm micellar s仃uctⅢe with controlled siZe and n的叩hobgies． 万方数据 PH响应性两亲性嵌段共聚物