pparγ抑制ckd血管钙化的作用和机制研究内科学肾病专业论文.docxVIP

第三军医大学硕士学位论文Ixg 第三军医大学硕士学位论文 Ixg microgramme 微克 mg milligram 毫克 g gram 克 埏 kilogram 千克 2 万方数据 第三军医大学硕士学位论文The 第三军医大学硕士学位论文 The role and mechanism of PPAR7 inhibiting CKD l●n VaSCUIar CalClllCatlon Abstract The incidence of chronic kidney disease(CKD)in China and the world is increasing year by year，and most of the patients will eventually develop into end-stage renal disease (ESRD)and receive renal replacement therapy．Compared with the general population，the incidence and mortality of cardiovascular disease in CKD patients were significantly increased．And rapid progression of vascular calcification is an important feature of cardiovascular disease in such patients．Therefore，it is of great significance to intervene the occurrence and development of vascular calcification in patients with CKD． Normal calcification occurs only in the bones and teeth，in addition to any place of calcification are abnormal calcification．The main feature of vascular calcification iS the pathological deposition of calcium phosphate in vascular tissue．Vascular calcification can occur in two areas of the vessel wall，the intima and the media。While patients with CKD can develop both types of vascular calcification，calcification of the media is more specific to CKD．The media is made up of smooth muscle cells in a framework of loose connective tissue．The main reason for the calcification of the media iS the differentiation of vascular smooth muscle cells(VSMCs)into osteoblasts．It was thought that CKD vascular calcification mainly occurred in ESRD and dialysis phase，but new studies have found that CKD vascular calcification can occur in the early stage 2 of CKD．In the late CKD， especially in uremic patients with severe mineral metabolic disorders，high phosphate and Ca×P product abnormalities are the characteristic inducement of VSMCs calcification． Many clinical studies have confirmed that high phosphate is an independent risk factor for CVD and all—cause mortality of CKD patients．In high phospho