多孔纤维素水凝胶微球的制备与性能研究材料学专业论文.docxVIP

摘要本文以反相悬浮聚合法，以羟丙基甲基纤维素(HPMC)为原料，二乙烯基砜 摘要 本文以反相悬浮聚合法，以羟丙基甲基纤维素(HPMC)为原料，二乙烯基砜 (DVS)为交联剂，聚甘油单硬脂酸酯为分散剂，环己烷为连续相，合成了水凝胶 微球。另外，分别通过以碳酸钙纳米粉末和封端的聚乙二醇为制孔剂，制备了多 孔纤维素水凝胶微球。 本文分为三个部分：反相悬浮工艺条件、碳酸钙制孔、封端聚乙二醇制孔。 在第一部分研究了反相悬浮工艺如温度、纤维素水相浓度及交联剂等对水凝胶微 球性能的影响，并探讨了反相悬浮的稳定因素及工艺条件对微球粒径变化的影 响。在制孔部分研究了制孔剂对多孔水凝胶微球表面及内部孔络结构、吸水速率、 吸水倍率、溶涨行为等微球性能的影响。对制孔机理进行探讨，制孔剂用量只有 达到一定程度后才可制备出具有贯穿孔结构的多孔微球。 通过对溶胀动力学的研究，更好的理解了水凝胶微球吸水溶胀的过程，理解 了微球表面及内部结构对溶胀行为的影响，比表面积的增大使得微球具有更高的 吸水速率。 采用红外光谱(IR)、扫描电镜(SEM)、差示扫描量热法(DSC)等方法对产物的 内部结构及表面结构、微球形态、比表面积进行了表征。 关键词：纤维素，水凝胶，微球，多孔 ABSTRACTThe ABSTRACT The HPMC hydrogel beads were prepared by inverse suspension polymerization， in which divinylsulfone(DVS)was used as crosslinker．The amphiphilic copolymer of Iripolyglycerol monostearate was used as dispersant and cyclohaxane was used as the organic phase．In addition，the porous hydrogels were prepared，in which calcium carbonate and polyethylene glycol were used as porosigen． There are three parts in this paper：The technics of inverse suspension polymerization,porous hydrogels prepared by calcium carbonate and porous hydrogels prepared by polyethylene glyc01．In the first part，the factors influencing the water absorption capacities of the hydrogels such as temperature，solution concentration．the amount of crosslinker were characterized．The factors which affect the stability of the polymerization and the factors which affect the particle size were also investigated．In the part of preparing porous hydrogels，the effect of porosigen on the surface and structures of the beads，swelling velocity,swelling degree and swelling kinetics were investigated．ne porous structure was made when the porosigen dosage reach the enough quantity．． 111e swelling kinetics was well investigated．The effect of structure and aspect area on swelling behavior was well characterized．As aspect area increased，the swelling velocity was increased． The surface structures，morphology of hydrogels beads and aspect area were characterized byⅡL SEM and DSC．etc． KEY WORDS