脂蛋白相关磷脂酶A2和动脉粥样硬化斑块形成、稳定性及病变程度关系.docVIP

脂蛋白相关磷脂酶A2和动脉粥样硬化斑块形成、稳定性及病变程度关系的探讨 王晓菲，张俊峰 (上海市宝山区漠河路280号，上海交通大学医学院附属第九人民医院 心内科，上海 201900) 摘要：目的：探讨血清脂蛋白相关磷脂酶A2(1ipoprotein-associated phospholipase A2，LP-PLA2)水平与冠状动脉病变的相关性及临床意义。方法：连续入选2015年1月至2015年7月我院收治的确诊或疑诊冠心病而行冠状动脉造影检查的患者202例，收集所有患者的病史资料、实验室数据以及冠状动脉造影检查结果。依据患者冠状动脉造影检查结果，将所有入选者分为对照组和实验组。对照组为冠脉造影50％者；实验组根据临床症状分为不稳定心绞痛、稳定性心绞痛以及急性心肌梗死组，根据病变情况分为单支、两支及三支病变组。比较各组LP-PLA2水平， 并计算Gensini积分，探讨各组患者血清Lp-PLA2水平与 Gensini积分的关系。结果：1）冠状动脉病变组的血清LP-PLA2水平显著高于对照组(P0.05)，实验组中，急性心肌梗死组血清LP-PLA2水平最高。2）单支、双支及三支病变组间的血清LP-PLA2水平差异无统计学意义。3)血清LP-PLA2浓度与冠状动脉Gensini评分存在正相关关系，Gensini评分越高，LP-PLA2水平越高。结论:血清 LpPLA2浓度与冠状动脉病变程度具有一定的相关性，检测血清Lp-PLA2水平可用于评估冠状动脉病变的进展。 关键词：冠状动脉疾病 ；脂蛋白相关性磷脂酶A2；冠状血管造影术; Gensini积分; 急性心肌梗死 通讯作者：张俊峰，主任医师，博士，硕士生导师，主要从事冠脉介入等方面的研究，Email：zhangjf1222@ 作者简介：王晓菲，硕士生，主治医师 Email： HYPERLINK mailto:wf840928@163.com wf840928@163.com 基金资助：此课题是由上海交通大学医学院附属第九人民医院院优青基金资助 A study on the relationship between lipoprotein associated phospholipase A2 and coronary artery disease Xiao-Fei Wang，Jun-Feng Zhang (Department of Cardiology, Ninth?Affiliated?Hospital,?Medical?College, Shanghai Jiao Tong University, Shanghai 201900,?China Abstract: AIM: To investigate the correlation between lipoprotein associated phospholipase A2 (LP-PLA2) concentration and coronary artery lesions, and to explore the clinical significance of Lp-PLA2 concentration. Method: 202 patients were selected from January 2015 to July 2015 in our hospital were diagnosed or suspected coronary heart disease and underwent coronary angiography, all patients were collected from medical records, laboratory data and the results of the coronary angiography. According to the results of coronary angiography, the patients were divided into the control group and the experimental group. According to the clinical symptoms, the experimental group was divided into unstable angina, stable angina and acute myocardial infarction group. According to the coronary artery lesions, the lesions were divided into single vessel lesion, two lesions and thre