分子印记聚合物的制备及其在药物检测中的应用无机化学专业论文.docxVIP

A A BSTRACT I ne sare u8e of drugs especially stimulant drugs has important significaJlce to assufe the human health． In recent years， with．increase of variety and quallti够of drugs，the problems which caused by drug abuse have risen considerable concems- HoweveL the established techniques are time．COnsumed 嘶th the employment of expensive equipments such as High Performance Liquid chromatography(HPLC)．Therefore，the development of sensitive robust sensor f-or real-time,trace analysis of drugs necessitates．Theophylline(THO)，also knoWn aS dimethylxanthine，is a methylxanthine drug therapy for resp砒oDr diseases．The mam acno璐of it involve：increasing heart rate，diuresis，dilating coron哪锄ew’ 坨鼢ng bronchial smooth muscle，stimulatory central nervous system．While，using too much may cause numerous side—effects．Herein，theophylline USed aS analvte． n锄oscale mol∞ularly imprinted polymers were synthesized，and combining with Surface．enhanced Raman Scattering technique，molecularly imprinted poIymers sensors for theophylline recongnition were also prepared． (1)Nanoscale molecularly imprinted polymers have mally a“antages，such as lligh denSlty of effective recognition sits and fast rebinding kinetics．Here．a Iayer-by。lay盯molecular imprinting strategy was used to synthesize the gelatin-building molecular recognition sites at the surface of silica particles．The 1mpnntlrig complex was prepared by intermolecular interaction between carboxyl 伊oup of gelatin and theophylline，then the imprinting complex was assembled onto the锄1ne。cal)plng silica particles by the covalent interaction between锄m group and aldehyde group providing by glutaraldehyde．The shell“ckness Can be m11ed at the nanomete¨cale by controlling the number of layers．The results showed t11at 1mprinted肌crospheres had recognition ability tO也eophylline，觚Id also had selectlVity t0 theophylline between theophylline and its analogues，ca氐inel The noVeJ molecuIar 1mprinting strategy built by protein provide a new approaching mimic of