丝状真菌二倍半萜化合物和其合成酶.PDFVIP

生 物 工 程 学 报 殷如 等/丝状真菌二倍半萜化合物及其合成酶 1631 Chinese Journal of Biotechnology /cjbcn December 25, 2016, 32(12): 1631−1641 DOI: 10.13345/j.cjb.160129 ©2016 Chin J Biotech, All rights reserved 综 述 殷如，洪葵 430071 , . . , 2016, 32(12): 1631–1641. Yin R, Hong K. Filamentous fungal sesterterpenoids and their synthases. Chin J Biotech, 2016, 32(12): 1631–1641. 摘 要: 相比其他萜类化合物，丝状真菌来源的二倍半萜化合物数量较少，但具有广泛的生理活性和药用价 值。已经发现的丝状真菌二倍半萜合成酶均由萜类环化酶和异戊烯基转移酶两个结构域组成，表现出底物的非 特异性和环化方式的多样性。本文重点叙述了丝状真菌来源的二倍半萜化合物以及其合成酶的结构与功能特 征，并对丝状真菌二倍半萜化合物及其合成酶研究现状作简要概述。 : 丝状真菌，二倍半萜化合物，二倍半萜合成酶 Filamentous fungal sesterterpenoids and their synthases Ru Yin, and Kui Hong Key Laboratory of Combinatorial Biosynthesis and Drug Discovery , Ministry of Education , School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China Abstract: Although the number of sesterterpenoids is fewer than other terpenoids reported, they have presented a wide range of biological activities and medicinal value. Reported filamentous fungal sesterterpene synthases are special on bifunctional two catalytically independent domains: prenyltransferase and terpene cyclase, but less specific on substrates selection and diverse ways of cyclization. This article reviews the research advances in filamentous fungal sesterterpenoids and their synthases, especially describes filamentous fungal sesterterpenoids and the structure and function characteristics of sesterterpene synthase. Keywords: filamentous fungi, sesterterpenoids, sesterterpene synthases Received: March 30, 2016; Accepted: May 4, 2016 Supported by: National High Technology Research and Development Program of China (8