不同剂量瑞舒伐他汀对急性冠脉综合征患者血NF-κB-中国现代应用药学.PDF

不同剂量瑞舒伐他汀对急性冠脉综合征患者血 NF-κB ，sICAM-1 表达 的影响 潘轶斌，包丽芳，陈杭，金烈，张向阳，华崇俊(金华市中心医院，浙江 金华 321001) 摘要：目的 探讨不同剂量的瑞舒伐他汀对急性冠脉综合征(ACS) 患者血核因子-κB(NF-κB) 、可溶性细胞间黏附因子 (sICAM-1)表达的影响。方法 ACS 患者随机分为瑞舒伐他汀10 mg 组和20 mg 组，另设健康对照组。治疗前及治疗后 检测血NF-κB ，sICAM-1 及血脂等指标，进行治疗前后比较及组间比较。结果 ACS 患者血NF-κB ，sICAM-1水平较健 康对照组显著升高(P0.01) ，治疗4 周后，瑞舒伐他汀 10，20 mg 组血NF-κB ，sICAM-1活性下降，治疗前后有显著性差 异。治疗后瑞舒伐他汀20 mg 组比 10 mg 组血NF-κB ，sICAM-1 水平下降更显著(P0.05) 。结论 瑞舒伐他汀能有效降 低ACS 患者血NF-κB ，sICAM-1 水平，且大剂量作用更明显。 关键词：瑞舒伐他汀；急性冠脉综合征；NF-κB ；sICAM-1 中图分类号：R969.4 文献标志码：A 文章编号：1007-7693(2011)06-0572-04 基金项目：浙江省金华市科技局科研项目(2009-3-026) 作者简介：潘轶斌，男，硕士，副主任医师 Tel:E-mail: jhpyb@ ·572 · Chin JMAP, 2011 June, Vol.28 No.6 中国现代应用药学2011 年 6 月第 28 卷第 6 期 Effect of Different Doses of Rosuvastatin on Blood NF-κB and sICAM-1 in Patients with Acute Coronary Syndrome PAN Yibin, BAO Lifang, CHEN Hang, JIN Lie, ZHANG Xiangyang, HUA Chongjun(Jinhua Municipal Central Hospital, Jinhua 321001, China) ABSTRACT: OBJECTIVE To investigate the effect of different doses of rosuvastatin with acute coronary syndrome (ACS) patients on blood nuclear factor of kappa-B(NF-κB) and soluble intercellular adhesion molecule-1(sICAM-1) expression. METHODS ACS patients were randomized into rosuvastatin 10 mg group and 20 mg group. And forty healthy people were set as control group. Levels of blood NF-κB and sICAM-1 and blood lipids were measured between before treatment and after treatment. RESULTS Levels of blood NF-κB and sICAM-1 in ACS patients were significantly higher than healthy control group(P0.01). After 4 weeks’ treatment, levels of blood NF-κB and sICAM-1 were decreased in rosuvastatin 10 mg group and 20 mg group. After treatment, levels of blood NF-κB and sICAM-1 were decreased more significantly in rosuvastatin 20 mg group than 10