基于氨基酸类手性固定相的制备-材料学专业论文.docxVIP

摘要鉴于合适高效的手性固定相对手性物质进行分离的重要性，本文以高分 摘要 鉴于合适高效的手性固定相对手性物质进行分离的重要性，本文以高分 予微球为媒介，通过键联合成出来的手性功能单体，来制各功能高分子微球 这一介质，将其作为手性固定相。 本文以氨基酸为原料，通过对手性侧基的设计合成出两种不同的手性可 聚合单体，即将氨基酸衍生化，然后将手性功能单体与不同尺寸的多孔(中 空)苯乙烯交联微球键合，制得手性配体交换色谱固定相。并用电镜和红外 光谱对固定相进行了表征。通过扫描电镜测定所得的微球粒径大小和分布来 看，我们实验所制得的高分子微球的结构是比较理想的：它们大小均匀，而 且表面多孔。这样的结构必将有助于手性分离的商效。 本文基于6种氨摹酸制备出了16种不同分子结构的手性功能单体，探讨 了他们的合成条件和反应机制。并且还将这些手性功能单体分别与苯乙烯共 聚，探讨了共聚物的结构；和不同尺寸性态的高分子微球(中空)键联，合 成了高分子的手性固定相。针对不同得结构，应用差示扫描量热仪(DSC)对 其与苯乙烯的共聚物进行了表征。从表征结果来看，这些手性功能单体的合 成是成功的，它们完全可以通过共聚反应的方式，与苯乙烯等反应合成出不 同粒径和形态的高分子微球(中空)，从而在高分子微球上达到键联功能基 团的目的。 关键词：氨基酸；共聚反应；手性识别；手性分离；手性源 ABSTRACTBecause ABSTRACT Because of the inlportance of the different chiral separation substances，we prepare the different chiral functional monomers by the little ball．and as chiral stationary phase． With the material mnino—acid，we synthesize two chiral 1110nemers which have different chiral polymer．We call it deriving from amino acid AM then we have get the functional monomer derived from lors of amino acid which bond the polystyrene small moleculer compounds partical，SO we get ligand exchange chromtograph．Finally，we use SEM alld IR and analyisd the result．The particle size an size distribution were determincd by using scanning electron microscope．and the results indicated that the micro—ball thatWe prepared is ideal．because that they are equality and there are many holes on its surface．Thus function is helpful for the chiral separation． This text is about that on the basis of the chiral function of preparing out 1 6 kinds of different molecular structure of 6 kinds of alnino acid，have reseach their condition of reaction and synthetic mechanisnl．And we make the functionary molecularity polymerize with the styrene，then 11esearch the structure of their copolynmers；And We also make the functionary molecularity polymerize the chiral stationary phase with differem sizes of little ball(or hollow microsphere)．In allusion to differem ilramework，we rese