心房颤动患者血清BNPhsCRPCK-MB的-第三军医大学学报.DOC

编号 刊用形式：论著 PAGE PAGE 4 文章编号：1000-5404(2009)2- - 心房颤动患者血清BNP、hsCRP、CK-MB的变化及意义 钟 淼1，2 ，史若飞2 （1重庆医科大学临床学院，重庆 400016；2重庆市急救医疗中心，重庆 400014） 摘 要：目的 探讨血清脑钠肽(BNP)、高敏C-反应蛋白（hsCRP）及肌酸激酶同工酶(CK-MB)在心房颤动(AF)患者血清中的浓度变化及临床意义。 方法 入选72例患者按照心电图诊断将其分为持续性房颤组（房颤组，n = 32）和窦性心律组（窦律组，n = 40），按照美国纽约心脏病学会(NYHA)心功能的分级标准，又分为心功能II级、心功能III级、心功能Ⅳ级3个亚组。采用酶联免疫吸附法(ELISA)、胶乳增强免疫透射比浊法、酶速率法分别测定BNP、hsCRP、CK-MB在各组血清中的浓度变化，对其结果进行统计分析。 结果 ①房颤组血清BNP、hsCRP水平明显高于窦律组(P ＜ 0.05)。在相同心功能亚组中房颤组血清BNP、hsCRP水平明显高于窦律组(P ＜ 0.01)。在2组的心功能亚组中血清BNP、hsCRP水平随着心功能NYHA分级增加而增高(P ＜ 0.01)。②房颤组血清CK-MB水平与窦律组血清CK-MB水平无明显差别（P ＞ 0.05），其心功能亚组之间亦无明显差别(P ＞ 0.05)。③房颤组BNP 、hsCRP 、CK-MB 3者之间无相关关系（P ＞ 0.05）。结论 BNP、hsCRP与心房颤动的发生和持续可能相关，可作为房颤病情的相对独立的检测指标。CK-MB与房颤的发生和发展可能无关。 关键词：心房颤动；脑钠肽；高敏C-反应蛋白；肌酸激酶同工酶MB 中图法分类：R541.3 文献标识码：A Variation and significance of serum BNP, hsCRP, CK-MB in patients with atrial fibrillation ZHONG Miao1,2 ,SHI Ruo-fei2 (1Chongqing Medical University, Chongqing 400016;2Chongqing Emergency Medical Center, Chongqing 400014,China) Abstract: Objective To explore the changes of serum levels of BNP, hsCRP, CK-MB in patients with atrial fibrillation and its significance. Methods 72 patients were divided into atrial fibrillation group (n=32) and sinus rhythm group (n=40) according to ECG. The two groups were divided into three subgroups(the NYHA class II, the NYHA class III and the NYHA class Ⅳ) according to the NYHA cardiac function class . Serum BNP, hsCRP, CK-MB levels in all patients were measured respectively by enzyme-linked immunosorbent assay (ELISA), immunoturbidimetric method and enzyme rate assay. Results 1 .The levels of serum BNP, hsCRP in atrial fibrillation group were significantly higher than those in sinus rhythm group (p 0.05).In the same NYHA class subgroup ,the levels of serum BNP, hsCRP in atrial fibrillation group were significantly higher than those in sinus rhythm group (p 0.01).The levels of serum BNP, hsCRP both