基于胆甾醇和聚乙二醇的两亲性嵌段共聚物的合成及其性质研究-材料学专业论文.docxVIP

武汉理工大学硕士学位论文Abstract 武汉理工大学硕士学位论文 Abstract Due to the unique amphipathicity and microphase separation of molecular stnlctl】re，amphiphilic block copolymers have strong self-assembling ability to form molecular orderly body,which make it become the hot topic of polymer research． Thus preparing the amphiphilic block copolymers with controlled molecular weight and distribution and designed s仇lcture is the critical condition to some related research．At present，the majority of block copolymers are diblock and triblock，the molecules with special咖c嘶ale rare；PEG is widely used in polymer modification, but the polymers with the PEG backbone are little．Besides，ordinary hydrophobic chain are always block chain,using cholesterol as the hydrophobic end which has massive steroidal structure． In this paper,we use two different ideas to synthesis novel amphiphilic block copolymers based on cholesterol and poly(ehtylene glyc01)，then the relationship between the polymer structure and properties Was studied．(1)Using cholesterol as the starting point，succinic anhydride Was used to modify the secondary hydroxyl group to produce monocholesterylsuccinate，and then the NHS activation were carried on． 111e structure of synthesized products were in accord wim the expectation,but the reaction condition with EDA need further dicussion．(2)First，acryloyl chloride and methoxy poly(ethylene glyc01)were used to synthesis the mPEG macromonomer． Then,0．5G and 1．0G ethanolamine dendrimers were prepared by the traditional ¨divergent method”．At the last，the Michael addition reaction Was achieved by the amino group and double bond．The structure of target product Was characterized by IR and NMR．The results indicated that because of the length and flexibility of PEG chain,which cause great steric hindrance and reactive sites were buried，SO the reaction was not ideal．The bigger the molecular weight is，the more difficult the Michael addition reaction is．(3)Linear single and double end—cappe