葡糖醛酸转移酶2B家族15UGT2B15基因D85Y-第三军医大学学报.DOC

UGT2B15基因D85Y多态性和前列腺癌关系的Meta分析 朱景振1*， 董宗明2*， 李龙坤3，刘 骞3 ，孙碧韶1 ，宋 波1（400038重庆，第三军医大学西南医院：全军泌尿外科研究所1，全军普通外科中心2；400037 重庆，第三军医大学新桥医院泌尿外科3） [摘要] 目的 评价UGT2B15基因D85Y(D85 to Y85)多态性和前列腺癌之间的相关性。方法 通过检索Pubmed、Embase、CBM数据库，对符合纳入标准的文章，使用优势比（ORs）和95%的可信区间（95% CI）进行相关性评价。采用Begg检验和Egger检验对各项研究的发表偏倚进行分析。结果 Meta分析中共纳入6篇文章（病例组817例，对照组1 000例），检测显示UGT2B15基因D85Y多态性和前列腺癌具有显著的相关性(Additive模型: OR=0.72, 95% CI=0.58-0.89; Dominant模型: OR=0.53, 95% CI=0.35-0.81; Recessive模型: OR=0.77, 95% CI=0.61-0.98; YY vs DD基因型: OR=0.53, 95% CI=0.32-0.88; YD vs DD基因型: OR=0.55, 95% CI=0.35-0.86)。结论 UGT2B15基因Y85可能是前列腺癌的保护因素。 [关键词] 葡糖醛酸转移酶2家族B15基因 [中图法分类号] [ Association between the UGT2B15 gene D85Y polymorphism and prostate cancer: a Meta-analysis Zhu Jingzhen1, Dong Zongming2，Li Longkun3, Liu Qian3, Sun Bishao1, Song Bo1 (1Urinary Surgery Research Institute, Southwest Hospital; 2Center of General Surgery, Southwest Hospital,Chongqing,400038; 3Department of Urology, Xinqiao Hospital; Third Military Medical University, Chongqing, 400037, China) [Abstract] Objective To assess the association between UGT2B15 gene D85Y polymorphism and prostate cancer. Methods By searching PubMed, Embase, and CBM databases, all of the eligible studies which conformed to our Inclusion criteria were havested. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Begg’s and Egger’s test were used to evaluate publication bias. Results A total of 6 articles (817 cases and 1,000 controls) were analyzed in our study. On the whole, significant associations between UGT2B15 gene D85Y polymorphism and prostate cancer were found in all genetic models (Additive model: OR=0.72, 95% CI=0.58–0.89; Dominant model: OR=0.53, 95% CI=0.35–0.81; Recessive model: OR=0.77, 95% CI=0.61–0.98; YY vs DD genotype: OR=0.53, 95% CI=0.32–0.88; YD vs DD genotype: OR=0.55, 95% CI=0.35–0.86). Conclusion The UDP glucuronosyltransferase 2 family, polypeptide B15 gene（UGT2B15）Y8