经皮给药用亲水性压敏胶的研制-高分子化学与物理专业论文.docxVIP

华中科技大学硕士学位论文 华 中 科 技 大 学 硕 士 学 位 论 文 II II Abstract The preparations and the properties of the hydrophilic polyacrylic ester pressure sensitive adhesives (PSAs) and a series of hydrophilic polymer blend PSAs were investigated in this thesis. Using thiamazole and diclofenac diethylamine as modle drugs, we studied the drug-release properties and in vitro percutaneous permeability of polyacrylic ester PSAs′drug-delivery. By physical mixing methods, two types of hybrid hydrophilic PSAs were prepared by using the hydrophilic polymers. FRIT showed that the hybrid of polyvinyl pyrrolidone and polyvin