静注甘露醇对兔脑出血脑水肿的影响-外科学(神经外科)专业论文.docxVIP

PAGE PAGE IV Abstract. Objective: To study if the cerebral edema can be alleviated by low dose mannitol in New Zealand white rabbits of intracerebral hemorrhage. Methods: Intracerebral hemorrhage（ICH） model of New Zealand white rabbits be established firstly . These rabbits were divided randomly into three large groups according to observational time. Rabbits in every large group were divided randomly into three therapeutic groups .In group A ,0.5g/kg mannitol was infused ,Q12h . In group B,0.25g/kg mannitol was infused ,Q12h . In group C ,no mannitol was used. The rabbits were executed by air embolism at 24、48、72、120 hours.Wet weights of brain tissues, which the volume was about 1 mm3,around the hematoma were weighted .Then ,the brain tissues were dried in an oven at 110℃ .Later ,dry weights of the brain tissues were weighted.At last , water content was calculated as the per centage change between wet weight and dry weight . Results ⑴ After being treated for 24 hours,water contents of the tissues around the hematoma of group A have significant difference compare with that of group B（p=0.075）.Yet,have no significant difference between group A and group C（p=0.450）. Synchronously, water contents of the tissues around the hematoma of group B have significant difference compare with that of group C（p=0.016）. ⑵ After being treated 48 hours, neither water contents of the tissues around the hematoma of group A have significant difference compare with that of group B（p=0.521）or group C（p=0.934）,.nor water contents of group B have significant difference compare with that of group C（p=0.719）. ⑶ After being treated 72 hours, neither water contents of the tissues around the hematoma of group A have significant difference compare with that of group B（p=0.112）or group C（p=0.420）,.nor water contents of group B have significant difference compare with that of group C（p=0.565）. ⑷ After being treated 120 hours, neither water contents of the tissues around the hematoma of group A