基于阿霉素–嵌段共聚物的多功能纳米载药体系及其性能研究.pdfVIP

Hans Journal of Nanotechnology 纳米技术, 2018, 8(3), 24-30 Published Online August 2018 in Hans. /journal/nat /10.12677/nat.2018.83004 Study of Multifunctional Nano-Drug Loading System and Its Properties Based on the Doxorubicin-Block Copolymer 1 1* 1 2 1 1 Chengkun Han , Huijuan Yan , Yufei Liu , Chunyan Li , Wenjun Li , Yajie Li 1 School of Pharmacy, Xinxiang Medical University, Xinxiang Henan 2 Pharmaceutical Comprehensive Laboratory, Sanquan College of Xinxiang Medical University, Xinxiang Henan th th st Received: Jul. 6 , 2018; accepted: Jul. 25 , 2018; published: Aug. 1 , 2018 Abstract Purpose: A novel multifunctional nano-drug loading system based on the doxorubicin-block copo- lymer was developed and its properties were also studied. Methods: Based on the principle of self-assembly of PMMA-co-MAA in aqueous solution to form “hydrophilic and hydrophobic” na- no-micelles. After all, the morphology and surface charge of nano-drug loading system were inves- tigated by TEM, DLS and zeta potential. At the same time, the properties were also investigated by UV and fluorescence spectroscopy. Results: The average diameter and surface charge of nanopar- ticles were about 50 nm and −36.9 mV, respectively. The maximum absorption wavelength is 478 nm and the maximum fluorescence emission wavelength is 563 nm. It has excellent optical prop- erties and good optical stability in buffer and serum. Conclusion: In this experiment, the optical properties and biocompatibility of drug were improved obviously by means of the encapsulation of hydrophobic DOX by copolymers, reducing side effects and