依达拉奉与奥拉西坦联合治疗急性脑梗死的临床研究.PDFVIP

中国现代医生 2019年2月第57卷第5期 窑内科医学 窑 依达拉奉与奥拉西坦联合治疗急性脑梗死的 临床研究 程海冰 山东省鲁西南医院神经内科袁山东聊城 252300 [摘要] 目的探讨依达拉奉联合奥拉西坦对急性脑梗死患者的疗效及对血清炎性因子与氧化应激指标的影响遥 方法选取我院2015年 1月耀2017年 1月收治的急性脑梗死患者 104例为研究对象袁均经临床检查确诊袁根据不 同治疗方法分为两组袁两组患者均给予抗感染尧脑细胞保护尧颅内压降低尧血压控制等常规治疗袁对照组渊n=52冤 给予奥拉西坦治疗袁观察组渊n=52冤在对照组基础上给予依达拉奉治疗袁对比两组患者临床疗效尧治疗前后炎症因 子水平以及氧化应激指标水平遥 结果两组患者总有效率渊90.38%vs 73.08%冤比较袁差异有统计学意义渊P0.05冤遥 治疗前两组患者TNF-琢尧IL-6水平比较差异无统计学意义渊P0.05冤曰治疗后观察组患者TNF-琢尧IL-6水平明显低 于对照组袁差异有统计学意义渊P0.05冤遥 治疗前两组患者MDA尧SOD水平比较差异无统计学意义渊P0.05冤曰治疗 后观察组患者MDA水平明显低于对照组袁SOD水平明显高于对照组袁差异具有统计学意义渊P0.05冤遥 结论依 达拉奉联合奥拉西坦两种药物可以进一步降低脑损伤袁促进神经功能恢复袁因此值得临床推广遥 [关键词]依达拉奉曰奥拉西坦曰急性脑梗死曰临床疗效曰血清炎性因子曰氧化应激指标 [中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701渊2019冤05-0045-03 Clinicalstudy onedaravonecombinedwithoxiracetaminthe treatmentof acutecerebralinfarction CHENGHaibing Departmentof Neurology,Southwestern Lu Hospitalin ShandongProvince, Liaocheng 252300, China [Abstract] Objective To investigate the effect of edaravone combined with oxiracetam on patients with acute cerebral infarction and the effect on serum inflammatoryfactors and oxidative stress indicators. Methods A total of 104patients with acute cerebral infarction admitted in our hospital from January 2015 to January 2017 were enrolled in the study. All patientswere diagnosed by clinical examination. They were divided into two groups according to different treatment methods. Both groups were given conventional treatments such as anti-infective and brain, cytoprotection, intracranial pressure reduction, and blood pressure control. The control group(n=52) was given oxiracetam. The observation group (n=52) was given edaravone on the