发生于胃的胃肠间质瘤外科治疗.docVIP

发生于胃的胃肠间质瘤外科治疗 临床医药实践杂志2006年9月第15卷第9期 bentassayforconnectivetissuegrowthfactor (CTGF)anditsdetectionintheseraofbiliaryatresia [J].BiochemBiophysResCommum,1998,251(3): 748. [4]SAEGUSA,ISAJIS,KAwARADAY.Changesin serumbyaalaronicacidlevelsandexpressionofCD44 MRNAinhepaticsinusoidalendothelialcellafter ? 661? majarhepatectomyincirrhoticrats[J].WorldJ Surg,2002,26(6):694—696. [5]BIOMIE,GOIDSCHMEDINGR,LCASKA.Gene regulationofconucotivetissuegrowthfactornew targetsforantifibrotictheraphy?[J].MATRIXBi— Ol,2002.21(6):4. 收稿日期:2006—07—03 作者简介:李蓉(197O一),女,内蒙古人,硕士学位,主治医生,主要从事消化内科工作. 文章编号;1671—8631(2006)09～0661—03 发生于胃的胃肠间质瘤外科治疗 韩学东 (南京医科大学附属淮安第一医院淮安市第一人民医院,江苏淮安223300) 摘要目的:探讨发生于胃的胃肠问质瘤(GIST)外科治疗的方法.方法:对1995年8月～2005年8月收治的经 手术病理证实的19例胃GIST进行回顾性研究.结果:19例患者中,肿瘤位于贲门胃底区7例,胃体9例,胃窦3例. 肿瘤最小2cm,最大25cm,中位大小6cm.胃周淋巴结转移1例.手术行胃楔形切除11例,近端胃大部切除5例, 远端胃大部切除3例,其中联合脏器切除3例.查免疫组织化学CDII7阳性l6例,CD34阳性I7例.术后随诊5例 复发转移.结论:胃GIST治疗以手术为主,术中应根据肿瘤大小,部位,有无外侵及淋巴结转移决定手术范围,切除在 于完全而不在于大范围清扫. 关键词胃肿瘤;问质瘤;外科治疗 中图分类号:R735.2文献标识码:B Surgicaltreatmentof2astrOintestinalstromaltumorsofstomach HANXue—dong (HuaianFirstHospitalAffiliatedtONanjingMedicalUniversity,HuaianFirstPeopleSHospital,Huaian223300,China) AbstractObjective:Toinvestigatethesurgicaltreatmentofgastr0intestinalstromaltumors(GIST)ofstomach. Methods:Theclinicaldataof19caseswithGISTofstomachwereanalyzedretrospectively.Results:Tomorswere foundbygastroscopy,bariummealandcomputertomography.ThepreoperationaldiagnosisofGISTwas13cases,and only4withpathologicalevidences.GISTlocatedatcardiaandgastricfundusin7cases,gastricbodyin9casesand gastricantrumin3cases.Diameteroftumorswasfrom2cmto25cm.Onlyonecasehadperigastriclymphnode metastasis.Allcasesunderwentresection,ofwhichwedgedresectionin11cases,distalsubtotalgastrectomyin3cas— es,proximalgastrectomyin5cases,conbinedwithotherorgansresectionin3cases.Immunohistochemistrystaining showedCD117positivein16cases,CD34positivein17cases.5casesrecurredormetastasized.Conclusion:Surgical approcchremainsthemajortreatmentforGISTofstomach.