更年甘露饮加小剂量雌激素对去势大鼠股骨的影响.docVIP

更年甘露饮加小剂量雌激素对去势大鼠股骨的影响 9 更年甘露饮加小剂量雌激素对去势大鼠股骨的影响 邹颖刚崔满华高鹏翔(吉林大学第二医院妇产科,吉林长春130041) [摘要】目的通过观察更年甘露饮加小剂量雌激素对去势大鼠股骨的影响,探索一种防治女性绝经期骨质疏松的新方法.方法雌性大 鼠切除双侧卵巢预防用药3个月,检测各组大鼠血清激素水平,股骨骨密度(BMD),光镜观察股骨结构,透射电镜观察子宫内膜腺上皮细胞超微结 构.结果小剂量雌激素无改善作用,更年甘露饮加小剂量雌激素,常规剂量雌激素及更年甘露饮均能改善血清激素水平,股骨BMD及结构,其中 更年甘露饮效果最弱,常规剂量雌激素对子宫内膜腺上皮细胞有明显刺激作用.结论更年甘露饮加小剂量雌激素改善去势大鼠血清激素水平,股 骨BMD及结构的作用与单纯使用雌激素相似,对子宫内膜腺上皮细胞无明显刺激作用,可作为一种防治绝经期后女性骨质疏松的新方法. 【关键词】绝经期;骨质疏松;更年甘露饮;雌激索 [中图分类号】R711.75[文献标识码】A[文章编号】1005-9202(2006)09-1249-03 TheeffectsofGENGNIANGANLUYINpluslow?doseestrogenonthefemurofovariectomizedrats ZOUYing?Gang,CUIMan?Hua,GAOPeng?xi蛆昏 DepartmentofObstetricsandGynecology,TheSecondClinicalHospitalofJilinUniversity,Changchun130021,Jmn,China 【Abstract】ObjectiveToinvestigatetlleeffectsofGENGNIANGANLUYINplUSlOW.doseestrclgenontllefemurofovariectomized ratsandtoapproachanewtreatmenttopreventmenopausalosteoporosis.MethodsWistarfemaleratswereovariectomizedandgivenmedi. cationfor3morttIls.Theserumestradlol(E,).follicle.stimulatinghormone(FSH),luteotrop(h)iChormone(LH)andbonemineraldensity (BMD)weredetected.femurstructurewereobservedbylightmicroscope,andendometrialglandularepitheliumultrastructurewereinvesfiga. tedbytransmissionelectronmicroscope.ResultsLow.doseestrogenhadnoobviouseffect.Norma1.doseestrogen,GENGNIANGANLUYIN, andGENGNIANGANLUYINpluslow-doseestrogenallcouldimproveserumhormoneandalleviatebonepathologicalchange.Amongtllose treatments.tlleeffectsofGENGNIANGANLUYINallonewasleastandnorma1.doseestrogenstimulatedendometriallglandularepitlleliaobvi. ously.ConclusionsGENGNIANGANLUYINpluslow.doseestrogenCanimproveserumhormoneandalleviatebonepathologicalchangehav. ingtllesimilareffectasnorma1.doseestrogenandhavenoobviousestrogenadversereactiononendometriallglandularepitllelia.whichCan serveasanewtreatmenttopreventmenopausalosteoporosis. 【Keywords】Menopause;Osteoporosis;GENGNIANGANLUYIN;Estrogen 绝经是女性生命进程中自然发生的生理过程,绝经后约有 25%的妇女患有骨质疏松.近年来现代医学主要应用激素替 代疗法(hormonereplacementtherapy,HRT)来防治女性因雌激素 缺乏所致的骨质疏松,HRT虽可有效防止骨质丢失,但由于长期 应