四-三氟乙烷氧基酞菁锌的光物理性质研究-中国现代应用药学.PDF

四-(三氟乙烷氧基)酞菁锌的光物理性质研究 吴晓珊，黄丽英* ，张锦雀(福建医科大学药学院，福州 350004) 摘要：目的 研究 2(3) ，9(10) ，16(17)，23(24)-四(三氟乙烷氧基)酞菁锌(ZnPcF)光物理性质( 包括紫外吸收光谱、荧光光 谱)和光敏化作用产生的单线态氧量子产率。方法 采用紫外-可见分光光度法和荧光分光光度法分别测定 ZnPcF 的紫外- 可见吸收光谱、荧光光谱；应用 9 ，10-二甲基蒽为捕捉单线态氧的探针，通过测定光敏化过程中探针浓度的变化，计算 ZnPcF 的单线态氧(1O )量子产率。结果 与酞菁锌(ZnPc)相比，ZnPcF 的紫外可见光谱和荧光光谱都有一定程度的红移。 2 4 1 1 ZnPcF 的摩尔消光系数(ε)为 1.65×10 L·mol ·cm ，荧光量子产率为 0.197 ，单线态氧量子产率为 0.547 。结论 ZnPcF 有 较大的摩尔消光系数、荧光及单线态氧量子产率，有进一步开发其抗肿瘤效果的前景。 关键词：四-(三氟乙烷氧基)酞菁锌；荧光量子产率；单线态氧量子产率；9 ，10-二甲基蒽 中图分类号：R913 文献标志码：B 文章编号 ：1007-7693(2010)10-0864-05 Photophysical Properties of Zinc 2(3),9(10),16(17),23(24)-Tetra(Trifluoroethoxy) Phthalocyaninate * WU Xiaoshan, HUANG Liying , ZHANG Jinque(College of Pharmaceutical, Fujian Medical University, Fuzhou 350004, China) ABSTRACT: OBJECTIVE The absorption spectral properties, fluorescence spectral properties and the singlet oxygen quantum yield in photo-induced chemical processes of Zinc 2(3),9(10),16(17),23(24)-tetra (trifluoroethoxy) phthalocyaninate (ZnPcF) were determined. METHODS UV and fluorescence spectrophotometrics were used to measure the UV spectrum, fluorescence spectrum. The concentration variation of singlet oxygen probe 9, 10-dimethylanthracene were measured by fluorescence spectrophotometric method to calculate the singlet oxygen quantum yield of ZnPcF. RESULTS There was certain magnitude of the redshift in absorption and fluorescence spectra of ZnPcF relative to unsubstituded ZnPc. The molar extinction coefficient of ZnPcF (ε) is 1.65×104 L·mol1·cm1, the fluorescence quantum yield is 0.197 and the singlet oxygen quantum yield is 0.547. CONCLUSION ZnPcF showed a very high molar extinction coefficient, fluorescence and singlet oxygen quantum yield with promi