Hp耐药与根除失败后耐药机制的分析.pdfVIP

摘要 23S 能与Hp对阿莫西林耐药有密切关系。⑦HprRNA中的2144位点的突变与克 等热点突变，也可能与克拉霉素耐药有关，前两种突变形式为首次报道。 rRNA 关键词：幽门螺杆菌；耐药基因；rdxA；pbplA；23S IV Abstract ABSTRACT and a Background Gram—negative， bacteriumthatcolonisesthestomachsof half microaerophilic，spiral approxunately theworld’s with isassociatedwithchronic population．InfectionH．pylori gastritis and ulcerationandthebacteriumisalsoconsideredariskfactorforthe peptic of adenocarcinomaandmucosa-associatedtissue development lymphoid gastric themosteffectivetreatment for (MALT)lymphoma．Currently re酉mensH．pylori combinea inhibitorandtwoantimicrobialselectedfrom protonpump agents amoxicillin，metronidazole，or finst—line is clarithromycin．Althoughoptimal therapy associatedwith cure ofresistancetoantibiotic high rates，therisingprevalence ofcurrenteradication threatensto the component regimensincreasingly compromise been researchesin ofthese have considerable efficacy regimens．Recently,there thefactorsthatdetermineantibiotic in unraveling susceptibilityH．pylori．These researchescomfhmthattheresistancetoantibioticswasassociatedwithmutationin