光动力疗法治疗酒渣鼻疗效观察皮肤病与性病学专业论文.docxVIP

上海交通大学医学院硕士学位毕业论文 上海交通大学医学院硕士学位毕业论文 PAGE PAGE 5 光动力疗法治疗酒渣鼻疗效观察 摘 要 研究目的 观察光动力疗法对不同类型（红斑毛细血管扩张型及丘疹脓疱型）酒 渣鼻的疗效，探讨其作用机制。将光动力疗法与外用磺胺醋酰钠、硫磺复 合剂作对比，确定光动力疗法的可行性及优势。 研究方法 收集酒渣鼻患者共 43 例，随机分成 2 组，其中 23 例行光动力治疗， 另 20 例通过传统外用药治疗。光动力组每周治疗 1 次，总共治疗三次； 传统外用药组患者每日用药 2 次，连续用药 30 天。治疗前后照相用以评 估疗效。全部治疗结束后由医生根据照片单盲评估症状改善程度，患者填 写 VAS 改善表作自身疗效评估。通过皮肤病生活质量指标量表评估患者生 活质量改善情况。记录副反应发生情况。 研究结果 光动力疗法治疗后痊愈率为 21.7％，有效率为 65.2％。其中对丘疹 脓疱型患者的有效率为 70.6％，对红斑毛细血管扩张型患者的有效率为 50％。传统外用药治疗后痊愈率为 10％，有效率为 35％。光动力疗法治 疗有效率显著高于传统外用药治疗 (P0．05)， 但两者治愈率无显著差 异 (P0．05)。VAS 改善评分结果示光动力疗法治疗组患者满意度高于传 统外用药治疗组。皮肤病生活质量指标量表计算结果示光动力治疗和传统 外用药治疗均使患者的生活质量得到改善，但光动力疗法治疗后患者生活 质量改善程度优于传统外用药治疗。光动力治疗和传统外用药治疗均没有 不可逆性副反应产生。 结论 光动力疗法治疗酒渣鼻安全有效，患者满意度高，明显改善患者生活 质量，其有效率高于传统外用药治疗。 关键词：光动力疗法，酒渣鼻，生活质量 THE CLINICAL EFFICACY OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF ROSACEA ABSTRACT Objectives To investigate the clinical HYPERLINK /pubmedefficacy of photodynamic therapy in the treatment of HYPERLINK /pubmeddifferent subtypes of rosacea (ie erythematotelangiectatic rosacea and papulopustular rosacea) by comparing its clinical efficacy with sodium sulfacetamide 10%/sulfur 5% emollient foam. Method 43 patients were enrolled in this study. Then they were divided randomly into 2 groups. 23 patients were treated with photodynamic therapy for 3 sessions with an interval of 1 week and the other 20 patients with sodium sulfacetamide 10%/sulfur 5% emollient foam 2 times per day for 30 days. Patients were assessed clinically and photographically by physicians. A quartile grading scale (VAS) and dermatology life quality index were completed by patients before and after treatment to evaluate patients’ satisfaction as well as the improvement of patients’ quality of life. The occurrences of side-effects were recorded during the treatment and follow-up. Result After the last treatment, the cure(more than 80％improvement) rate for PDT was 21.7％in total ,its effective (more than 60％improvement)rate was 65.2％in total，70.6％in erythematotelang