乙醛酸合成对羟基苯乙酸的研究-河北工业科技.PDF

22 5 河 北 工 业 科 技 V ol . 22, No . 5 2005 9 H ebei J our nal of Indu str ial Science and T echno log y Sept . 2005 1008- 1534( 2005) 05-0264- 03 , , , , ( 中昊宣化化工有限公司, 河北宣化 07 5100) 研究了由乙醛酸和苯酚合成对羟基扁桃酸 后, 再经亚磷酸还原, 合成对羟基苯乙酸的工 艺研究结果表明 在合适的工艺条件下, 由乙醛酸到对羟基苯乙酸的摩尔收率达60. 1% 对羟 基苯乙酸的质量分数可以达到99% 该法原料来源广, 产品质量好, 具有较好的发展前景 乙醛酸; 还原; 亚磷酸; 对羟基苯乙酸 T Q215 A Study of 4-hydroxyphenylacet ic acid sy nthsis from gly ox alic acid Q IA O X-i lo ng , T IA N H u i, LI Wen , ZH A O Xiu- yun , ZH A N G J in- fang ( China Hao hua G roup Xu anhu a Co mpany L im ited, Xu anhu a Hebei 075100 , China) Abstract: T he article st udies the sy nt hesis of 4- hydro xy phenylacetic acid , w hich is obtained fr om p- hydrox y m andelate sodium reduced by pho sphor ou s acid , and glyo xalix acid and pheno l produ ct s p- hy dr ox ym andelate so dium . U nder f itable co ndit ion , the 4- hy dr ox ypheny lacetic yield based g ly ox alix acid is 60. 1 p er cent , and chrom ato g ram co ntent o f 4- hydrox y phenylacetic acid is 99 per cent . T he raw m aterial source is w ide, the pr oduct quantity is g ood , and it h as t he better developm ent f o reg round. Key words: glyox alic; r edu ction ; phospho ro us acid ; 4- hydrox y phenylacetic acid 3) [ 2] , , , 149 ~ , , ; 153 , 152 , , , 4 , 7- ; , , , , [ 1] , , , 3 1) 1 , , 2) , 2004-06- 20; 2005- 03- 13