血液透析联合血液灌流治疗尿毒症患者皮肤瘙痒的疗效观察.docxVIP

血液透析联合血液灌流治疗尿毒症患者皮肤瘙痒的疗效观 陈蕊毕光宇孔亚玲 (江苏省苏北人民医院 江苏扬州225009) 【摘要】冃的：观察血液透析联合血液灌流治疗尿毒症患者皮肤瘙痒的疗效。 方法：将2012年2月?2014年1月间在本院进行维持性血液透析并出现皮肤瘙 痒的80例尿毒症患者随机分为治疗组(n=40)和对照组(n=40),治疗组患者采 用血液透析联合血液灌流治疗，对照组患者给予血液透析治疗。结果：治疗组患 者的皮肤瘙痒症状明显改善，血beta;2微球蛋白(beta;2?MG)、甲状旁腺激素 (PTH)、血肌酹(Scr)和尿素氮(BUN)均显著低于对照组患者(Plt;0.05), 但是两组患者Z间的血钙没有显著差异(Pgt；0.05)o结论：血液透析联合血液 灌流可以显著改善尿毒症患者的皮肤瘙痒，值得在临床推广应用。 【关键词】血液透析 血液灌流 尿毒症 皮肤瘙痒 【屮图分类号】R459.5 【文献标识码】A 【文章编号】2095-1752 (2014) 21-0356-02 Effects of hematodialysis and hemoperfusion on skin itch in patients with uremia CHEN Ruil,BI Guang-yu,KONG Ya?lin (Department of Nephrology,SubeiPeopless Hospital,Yangzhou, Jiangsu 225009,CHINA) 【Abstract] Objective:To observe the effects of hematodialysis and hemoperfusion on skin itch in patients with uremia. Methods:80 patients with uremia undergoing hemodialysis in Blood Purfication Center of SubeiPeopless Hospital from February 2012 to January 2014 were randomly divided into treatment group(n二40) and control group(n二40).Treatment group was given hematodialysis and hemoperfusion therapy and control group was given hematodialysis therapy? Results: The treatment group patients with itchy skin symptoms improved significantly. The beta;2-MG, PTH, Scr, BUN level of the treatment group were significantly lower than those of the control group(Plt;005).However;there was no significant differenee in Ca2+ between two groups(Pgt;0.05). Conclusions:The hematodialysis and hemoperfusion in treatment with skin itch has a better effect,which can be used preferred method to treat skin itch with uremia. 【Key words] hematodialysis hemoperfusion uremia skin itch 皮肤瘙痒是维持性血液透析的尿毒症患者最常见的临床症状之一，早期研究 报告尿毒症瘙痒症发生率为22-86%? DOPPS I和DOPPS II研究分别报告维持性血 液透析患者瘙痒症发生率高达45%和42%O尿毒症瘙痒症严重影响患者生活质量, 同时研究还显示尿毒症瘙痒症是尿毒症患者死亡的一个不可忽视的相关因素⑴。 虽然皮肤瘙痒不是导致尿毒症患者死亡的直接因素，但它作为一个相关因素已经 普遍被人民重视。临床上采用药物治疗，但其治疗效果不理想，近年来我院采用 血液透析联合血液灌流治疗尿毒症患者的皮肤瘙痒取得了良好的疗效，现报道如 下。 1资料与方法 1.1 一般资料 选择2012年2月?2014年1月间在我院进行维持性血液透 析并出现皮肤瘙痒的80例尿毒症患者，随机分成治疗组和对照组。其中治疗组 40例，男23例,女17例，年龄(32?78)岁，平均年龄(56.22p