冠脉介入治疗对缺血性心肌病患者循环内皮祖细胞、缺血修饰蛋白及心功能的影响-内科学专业论文.docxVIP

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冠脉介入治疗对缺血性心肌病患者循环内皮祖细胞、缺血修饰蛋白及心功能的影响-内科学专业论文.docx

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Abstractobjective：This Abstract objective：This thesis attempts to observe the change of CEPCs number,IMA and cardiac function for a patient with ICM at different times before and after PCI；to investigate the effect of PCI on CEPCs number,IMA and Cardiac Function,and further analyze the correlation between cardiac function and CEPCs，IMA． Method：The patients wkh ICM，and diagnosed under the coronary angiography with multivessel several coronary artery stenosis were selected．The patients who further received PCI were set as the PCI group(PCI)，while the patients who not received PCI were set as the control group(CG)．The control group will received drug therapy only． The PCI group will received drug therapy and PCI operation．All of the patient were not take ACEI，ARB，Statin pre—admission。The clinical data of subjects were collected，with the signature on informed consent，Coronary angiography was performed using Judkins method，the degree of coronary artery stenosis was measured through the quantitative computer analysis(QcA)．1 0ml peripheral blood Was collected and drawn into EDTA anticoagulant tube at admission and at 3d and 7d after the PCI operation／drug therapy respectively in the two group，and the PCI group also collect 1 0ml peripheral blood at 24 h，48 h after the PCI operation．Numbered and then kept in-70℃refrigerator,CEPCs surface markers CD34，KDR，and IMA and relevant biochemical indexes were detected using flow cytometry；LVEDD and LVEF at admission and at 3d，7d after the PCI operation／drug therapy were determined through the M-echocardiography． Results： 1．(D The FCM show that the number of CD34+KDR+CEPCs for patients of PCI group at admission,at 24h,48h，3d and 7d after the PCI operation was 3．135+0．906 VS 3．894+0．776 VS 4．382+0．977 VS 4．629士0．825 VS 4．605士0．766(％、 respectively,and there was a statistical significance at 24h,48h，3d and 7d after the PCI operation than at admission伊O．05)．⑦The FCM show that number of CEPCs Ill 万方数据 for for patients of control group at